Evidence map›Paper›PMID 25139822›Full record

ArticlePain medicine (Malden, Mass.)2014

Mechanisms underlying chronic whiplash: contributions from an incomplete spinal cord injury?

James M Elliott, Julius P A Dewald, T George Hornby, David M Walton, Todd B Parrish

Abstract readCase Reports
In one paragraph

Article in Pain medicine (Malden, Mass.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Biopsychosocial sequelae and recovery trajectories from whiplash injury following a motor vehicle collision.The spine journal : official journal of the North American Spine Society · 2023
    Article
  8. Article
  9. Article
  10. Spinal cord injury is not a feature of chronic whiplash-associated disorder: a magnetic resonance spectroscopy study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Advancing imaging technologies for patients with spinal pain: with a focus on whiplash injury.The spine journal : official journal of the North American Spine Society · 2018
    Review
  15. Article
  16. Article
  17. An Integrated Model of Chronic Whiplash-Associated Disorder.The Journal of orthopaedic and sports physical therapy · 2017
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James M ElliottDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Julius P A Dewald
T George Hornby
David M Walton
Todd B Parrish

Funding

Multidisciplinary Clinical and Translational Science (MCTS) Program (KL2)KL2RR025740 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREENLAND, PHILIP · 2008 to 2011
$2.8M
Neuromuscular Mechanisms Underlying Poor Recovery from Whiplash InjuriesR01HD079076 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COURTNEY, D. MARK, ELLIOTT, JAMES MATTHEW · 2014 to 2018
$1.6M
Multidisciplinary Clinical and Translational Science (MCTS) Program (KL2)KL2TR000107 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$1.1M
NCATS NIH HHS KL2 TR000107NCRR NIH HHS KL2 RR025740NICHD NIH HHS R01 HD079076
6 · The paper itself

Abstract

objectiveTo explore the association between findings on advanced, but available, magnetic resonance imaging (MRI) sequences of the cervical spinal cord and muscular system, in tandem with biomechanical measures of maximum volitional plantar flexion torques as a proxy for a mild incomplete spinal cord injury.

designObservational case series.

settingUniversity research laboratory. SUBJECTS: Three patients with chronic whiplash and one patient with history of whiplash injury but no current symptoms.

methodsWe measured lower extremity muscle fat, morphological changes in descending spinal cord pathways with advanced MRI applications and maximal activation of the plantar flexors.

resultsLarger magnitudes of lower extremity muscle fat corresponded to altered spinal cord anatomy and reductions in the ability to maximally activate plantar flexor torques in the three subjects with chronic whiplash. Such findings were not present in the recovered participant.

conclusionsThe potential value of MRI to quantify neuromuscular degeneration in chronic whiplash is recognized. Larger scaled prospective studies are warranted before stronger conclusions can be drawn.

Indexed as

AdultCervical VertebraeChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleSpinal Cord InjuriesWhiplash InjuriesMRINeck (Pain)NeurologySpinal CordWhiplash

Identifiers

PMID25139822
PMCPMC6597006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.