Trial reportCritical care (London, England)2014
Insulin treatment guided by subcutaneous continuous glucose monitoring compared to frequent point-of-care measurement in critically ill patients: a randomized controlled trial.
Trial report in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continuous Glucose Monitoring by Subcutaneous Measurement Compared to Frequent Point of Care Measurement by Accu Chek in Critically Ill Patients; a Randomized Controlled Trial (RESCUEII)
Continuous Glucose Monitoring in the Hospital to Aid in Care and Improve Transition of Care to Outpatient
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Effects of Continuous Versus Intermittent Glucose Monitoring in Intensive Care Unit Patients: A Systematic Review With Meta-Analysis.Acta anaesthesiologica Scandinavica · 2026Pooled it
- Continuous peri-operative glucose monitoring in noncardiac surgery: A systematic review.European journal of anaesthesiology · 2025Pooled it
- Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline.Journal of diabetes science and technology · 2020Guideline
- Composite Metric of Glycemic Control Q-Score Is Elevated in Pediatric and Adolescent/Young Adult Hematopoietic Stem Cell Transplant Recipients.Diabetes technology & therapeutics · 2023Trial
- Accuracy and reliability of a subcutaneous continuous glucose monitoring device in critically ill patients.Journal of clinical monitoring and computing · 2018Trial
- Trial
- Accuracy of 2 Different Continuous Glucose Monitoring Systems in Patients Undergoing Cardiac Surgery.Journal of diabetes science and technology · 2017Trial
- Association of continuous glucose monitoring with in-hospital adverse outcomes among critically ill patients: a real-world propensity score-matched study.Frontiers in endocrinology · 2026Article
- Endocrinologist-led glucose management in the emergency ICU: a retrospective before-after study.Frontiers in endocrinology · 2026Article
- Performance and clinical relevance of continuous glucose monitoring during early brain injury in subarachnoid hemorrhage.Scientific reports · 2025Article
- Continuous glucose monitoring during intravenous insulin infusion treatment: Assessing accuracy to enable future clinical utility.Diabetic medicine : a journal of the British Diabetic Association · 2025Observational
- Continuous interstitial glucose monitoring in diabetic and non-diabetic critically ill patients is simple and accurate: comparison with venous, arterial and capillary glucose measurements.Acta diabetologica · 2025Observational
- Rapid increase in continuous glucose monitoring use among adults with type 1 diabetes admitted to hospital: a Melbourne multicentre observational study.Internal medicine journal · 2025Article
- Accuracy of continuous glucose monitoring systems in intensive care unit patients: a scoping review.Intensive care medicine · 2024Article
- Consensus Considerations and Good Practice Points for Use of Continuous Glucose Monitoring Systems in Hospital Settings.Diabetes care · 2024Review
- Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China.Journal of intensive medicine · 2024Article
- Continuous glucose monitor accuracy during extracorporeal membrane oxygenation.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- A Consensus Statement for Continuous Glucose Monitoring Metrics for Inpatient Clinical Trials.Journal of diabetes science and technology · 2023Article
- Nursing Perspectives on the Use of Continuous Glucose Monitoring in the Intensive Care Unit.Journal of diabetes science and technology · 2023Article
- Continuous Glucose Monitoring in the Intensive Care Unit.Journal of diabetes science and technology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGlucose measurement in intensive care medicine is performed intermittently with the risk of undetected hypoglycemia. The workload for the ICU nursing staff is substantial. Subcutaneous continuous glucose monitoring (CGM) systems are available and may be able to solve some of these issues in critically ill patients.
methodsIn a randomized controlled design in a mixed ICU in a teaching hospital we compared the use of subcutaneous CGM with frequent point of care (POC) to guide insulin treatment. Adult critically ill patients with an expected stay of more than 24 hours and in need of insulin therapy were included. All patients received subcutaneous CGM. CGM data were blinded in the control group, whereas in the intervention group these data were used to feed a computerized glucose regulation algorithm. The same algorithm was used in the control group fed by intermittent POC glucose measurements. Safety was assessed with the incidence of severe hypoglycemia (<2.2 mmol/L), efficacy with the percentage time in target range (5.0 to 9.0 mmol/L). In addition, we assessed nursing workload and costs.
resultsIn this study, 87 patients were randomized to the intervention and 90 to the control group. CGM device failure resulted in 78 and 78 patients for analysis. The incidence of severe glycemia and percentage of time within target range was similar in both groups. A significant reduction in daily nursing workload for glucose control was found in the intervention group (17 versus 36 minutes; P <0.001). Mean daily costs per patient were significantly reduced with EUR 12 (95% CI -32 to -18, P = 0.02) in the intervention group.
conclusionsSubcutaneous CGM to guide insulin treatment in critically ill patients is as safe and effective as intermittent point-of-care measurements and reduces nursing workload and daily costs. A new algorithm designed for frequent measurements may lead to improved performance and should precede clinical implementation.
trial registrationClinicaltrials.gov, NCT01526044. Registered 1 February 2012.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.