ArticleJournal of neural transmission (Vienna, Austria : 1996)2015
Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A Two-Hit Approach Inducing Flurothyl Seizures in Fmr1 Knockout Mice Impacts Anxiety and Repetitive Behaviors.Brain sciences · 2024Article
- The outcome of early life status epilepticus-lessons from laboratory animals.Epilepsia open · 2023Article
- Article
- Learning Deficits and Attenuated Adaptive Stress Response After Early-Life Seizures in Zebrafish.Frontiers in neuroscience · 2022Article
- Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions.International journal of molecular sciences · 2021Review
- Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function followingData in brief · 2020Article
- Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures.Frontiers in behavioral neuroscience · 2020Article
- Taurine/Pilocarpine Interaction in the Malnourished Rat Brain: A Behavioral, Electrophysiological, and Immunohistochemical Analysis.Frontiers in neuroscience · 2019Article
- Autistic traits in epilepsy models: Why, when and how?Epilepsy research · 2018Review
- Sub-Convulsing Dose Administration of Pilocarpine Reduces Glycemia, Increases Anxiety-Like Behavior and Decelerates Cortical Spreading Depression in Rats Suckled on Various Litter Sizes.Frontiers in neuroscience · 2018Article
- Effect of diazepam on sociability of rats submitted to neonatal seizures.Data in brief · 2016Article
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Authors and funding
4 authors.
Funding
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Abstract
Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality.
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