ArticleImmunogenetics2014
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.
Article in Immunogenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- A systematic review and modelling insights of factors impacting measles vaccine effectiveness, efficacy and immunogenicity.Discover viruses · 2025Review
- Vaccinomics: Paving the Way for Personalized Immunization.Current pharmaceutical design · 2024Review
- Vaccinomics: A scoping review.Vaccine · 2023Article
- CD14 Is Involved in the Interferon Response of Human Macrophages to Rubella Virus Infection.Biomedicines · 2022Article
- Pharmacogenomics and Vaccine Development.Clinical pharmacology and therapeutics · 2021Article
- Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.NPJ precision oncology · 2021Article
- Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Frontiers in immunology · 2021Review
- Article
- The science and medicine of human immunology.Science (New York, N.Y.) · 2020Review
- Systems vaccinology and big data in the vaccine development chain.Immunology · 2019Review
- Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy.Journal for immunotherapy of cancer · 2017Review
- Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon.World journal of hepatology · 2016Article
- In silico Analysis Revealed High-risk Single Nucleotide Polymorphisms in Human Pentraxin-3 Gene and their Impact on Innate Immune Response against Microbial Pathogens.Frontiers in microbiology · 2016Article
- Does Rubella Cause Autism: A 2015 Reappraisal?Frontiers in human neuroscience · 2016Review
- Variability in Humoral Immunity to Measles Vaccine: New Developments.Trends in molecular medicine · 2015Review
- Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children.Immunogenetics · 2015Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Single-nucleotide polymorphisms (SNPs) in candidate immune response genes were evaluated for associations with measles- and rubella-specific neutralizing antibodies, interferon (IFN)-γ, and interleukin (IL)-6 secretion in two separate association analyses in a cohort of healthy immunized subjects. We identified six SNP associations shared between the measles-specific and rubella-specific immune responses, specifically neutralizing antibody titers (DDX58), secreted IL-6 (IL10RB, IL12B), and secreted IFN-γ (IFNAR2, TLR4). An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. We also identified associations between individual SNPs in the IFNAR2 and TLR4 genes that were associated with IFN-γ secretion for both measles and rubella vaccine-specific immune responses. These results are the first to indicate that there are SNP associations in common across measles and rubella vaccine immune responses and that SNPs from multiple genes involved in innate and adaptive immune response regulation may contribute to the overall human antiviral response.
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