ArticleCancer prevention research (Philadelphia, Pa.)2014
Widefield optical imaging of changes in uptake of glucose and tissue extracellular pH in head and neck cancer.
Article in Cancer prevention research (Philadelphia, Pa.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides.Frontiers in pharmacology · 2024Review
- L-Glucose: Another Path to Cancer Cells.Cancers · 2020Review
- pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- In-vivo topical mucosal delivery of a fluorescent deoxy-glucose delineates neoplasia from normal in a preclinical model of oral epithelial neoplasia.Scientific reports · 2018Article
- Detection of Head and Neck Cancer in Surgical Specimens Using Quantitative Hyperspectral Imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Label-free reflectance hyperspectral imaging for tumor margin assessment: a pilot study on surgical specimens of cancer patients.Journal of biomedical optics · 2017Article
- Applications of pHLIP Technology for Cancer Imaging and Therapy.Trends in biotechnology · 2017Review
- Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP(®) Peptides) Conjugated with Different Fluorescent Dyes.Molecular imaging and biology · 2016Article
- Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney.American journal of physiology. Renal physiology · 2016Article
- The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance.Nature communications · 2015Article
- Identification of cancerous gastric cells based on common features extracted from hyperspectral microscopic images.Biomedical optics express · 2015Article
- Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP.Archives of biochemistry and biophysics · 2015Article
- Tumor margin assessment of surgical tissue specimen of cancer patients using label-free hyperspectral imaging.Proceedings of SPIE--the International Society for Optical EngineeringArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The overall objective of this study was to develop an optical imaging approach to simultaneously measure altered cell metabolism and changes in tissue extracellular pH with the progression of cancer using clinically isolated biopsies. In this study, 19 pairs of clinically normal and abnormal biopsies were obtained from consenting patients with head and neck cancer at University of California, Davis Medical Center. Fluorescence intensity of tissue biopsies before and after topical delivery of 2-NBDG (2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose) and Alexa 647-pHLIP [pH (low) insertion peptide] was measured noninvasively by widefield imaging, and correlated with pathologic diagnosis. The results of widefield imaging of clinical biopsies demonstrated that 2-NBDG and pHLIP peptide can accurately distinguish the pathologically normal and abnormal biopsies. The results also demonstrated the potential of this approach to detect subepithelial lesions. Topical application of the contrast agents generated a significant increase in fluorescence contrast (3- to 4-fold) in the cancer biopsies as compared with the normal biopsies, irrespective of the patient and location of the biopsy within a head and neck cavity. This unpaired comparison across all the patients with cancer in this study highlights the specificity of the imaging approach. Furthermore, the results of this study indicated that changes in intracellular glucose metabolism and cancer acidosis are initiated in the early stages of cancer, and these changes are correlated with the progression of the disease. In conclusion, this novel optical molecular imaging approach to measure multiple biomarkers in cancer has a significant potential to be a useful tool for improving early detection and prognostic evaluation of oral neoplasia.
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