ArticleEcotoxicology (London, England)2014
Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub-lethal doses of the insecticide fipronil.
Article in Ecotoxicology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- Assessing spinosad effect on honey bee olfactory conditioning using a microcontroller-based device.Frontiers in insect science · 2026Article
- Parasite and Pesticide Impacts on the Bumblebee (International journal of molecular sciences · 2023Article
- Mass Spectrometry-Based Peptide Profiling of Haemolymph fromMolecules (Basel, Switzerland) · 2022Article
- An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems.Environmental science and pollution research international · 2021Review
- Modification of the head proteome of nurse honeybees (Apis mellifera) exposed to field-relevant doses of pesticides.Scientific reports · 2020Article
- The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees.International journal of molecular sciences · 2019Review
- Nosema ceranae, Fipronil and their combination compromise honey bee reproduction via changes in male physiology.Scientific reports · 2017Article
- Current knowledge of detoxification mechanisms of xenobiotic in honey bees.Ecotoxicology (London, England) · 2017Review
- Proteomic analysis in the Dufour's gland of Africanized Apis mellifera workers (Hymenoptera: Apidae).PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. (1)/100 of LD50/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.