ArticleReproductive sciences (Thousand Oaks, Calif.)2014
Enodthelin 1 is elevated in plasma and explants from patients having uterine leiomyomas.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Association of uterine fibroids with increased blood pressure: a cross-sectional study and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Pooled it
- Uterine fibroids and hypertensive disorders of pregnancy: Persistence of risk regardless of myomectomy or fibroid location.Pregnancy hypertension · 2026Article
- Hypoxia in uterine fibroids: role in pathobiology and therapeutic opportunities.Oxygen (Basel, Switzerland) · 2024Article
- Relationship Among Surgical Fibroid Removal, Blood Pressure, and Biomarkers of Renin-Angiotensin-Aldosterone System Activation.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Pathways of Hypoxia-Inducible Factor (HIF) in the Orchestration of Uterine Fibroids Development.Life (Basel, Switzerland) · 2023Review
- The relationship between muscle sympathetic nerve activity and systemic hemodynamics is altered in women with uterine fibroids.Physiological reports · 2022Article
- Differential response to hypoxia in leiomyoma and myometrial cells.Life sciences · 2022Article
- Uterine fibroids are associated with increased risk of pre-eclampsia: A case-control study.Frontiers in cardiovascular medicine · 2022Article
- Vascular biology of uterine fibroids: connecting fibroids and vascular disorders.Reproduction (Cambridge, England) · 2021Review
- Novel treatment avenues for uterine leiomyoma: a new implication for endothelin?Clinical science (London, England : 1979) · 2018Article
- Tumor characterization by ultrasound-release of multiple protein and microRNA biomarkers, preclinical and clinical evidence.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine a role for endothelin (ET) in progression of uterine fibroids.
designAn in vitro model of fibroid and myometrium cultivation. PATIENTS: A total of 32 women undergoing hysterectomies for uterine fibroids and 11 women undergoing hysterectomies for abnormal uterine bleeding (control population).
resultsWomen with uterine fibroids were hypertensive and displayed significantly greater circulating ET-1 compared to control patients. Secretion of ET-1 was greater from the fibroids compared to myometrium explants. Endothelin 1 secretion was attenuated with blockade of the angiotensin II type 1 or endothelinA receptors. Hypoxia stimulated ET-1 secretion from both myometrium and fibroid explants. Preproendothelin messenger RNA expression increased with hypoxia from fibroid explants compared to normoxic controls.
conclusionsThese data support the hypothesis that uterine fibroids are associated with hypertension and increased ET-1, which is exacerbated with hypoxia. These data suggest a possible link between mechanisms of blood pressure regulation and development of uterine leiomyoma.
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Registered trials
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