Evidence map›Paper›PMID 25138755›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2015

Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.

Matthew T Silvestrini, Dali Yin, Alastair J Martin, Valerie G Coppes, Preeti Mann, Paul S Larson, Philip A Starr, Xianmin Zeng, Nalin Gupta, S S Panter and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Matthew T Silvestrini1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA [2] Present address: Department of Bioengineering, University of California, Davis, Davis, California, USA.
Dali YinDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Alastair J MartinDepartment of Radiology, University of California, San Francisco, San Francisco, California, USA.
Valerie G Coppes1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Surgery, Veteran's Affairs Medical Center, San Francisco, California, USA.
Preeti Mann1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Surgery, Veteran's Affairs Medical Center, San Francisco, California, USA.
Paul S Larson1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Surgery, Veteran's Affairs Medical Center, San Francisco, California, USA.
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Xianmin ZengBuck Institute for Research on Aging, Novato, California, USA.
Nalin GuptaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
S S Panter1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Surgery, Veteran's Affairs Medical Center, San Francisco, California, USA.
Tejal A DesaiDepartment of Bioengineering, University of California, San Francisco, San Francisco, California, USA.
Daniel A Lim1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Surgery, Veteran's Affairs Medical Center, San Francisco, California, USA [3] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, San Francisco, California, USA.
University of California, San Francisco · USNeurological Surgery · USBuck Institute for Research on Aging · USSan Francisco VA Medical Center · USUniversity of California, Davis · US

Funding

Chromatin-based cellular memory in neural stem cellsDP2OD006505 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2009 to 2009
$2.3M
NIH HHS 1DP2OD006505-01NIH HHS DP2 OD006505
6 · The paper itself

Abstract

Intracerebral cell transplantation is being pursued as a treatment for many neurological diseases, and effective cell delivery is critical for clinical success. To facilitate intracerebral cell transplantation at the scale and complexity of the human brain, we developed a platform technology that enables radially branched deployment (RBD) of cells to multiple target locations at variable radial distances and depths along the initial brain penetration tract with real-time interventional magnetic resonance image (iMRI) guidance. iMRI-guided RBD functioned as an "add-on" to standard neurosurgical and imaging workflows, and procedures were performed in a commonly available clinical MRI scanner. Multiple deposits of super paramagnetic iron oxide beads were safely delivered to the striatum of live swine, and distribution to the entire putamen was achieved via a single cannula insertion in human cadaveric heads. Human embryonic stem cell-derived dopaminergic neurons were biocompatible with the iMRI-guided RBD platform and successfully delivered with iMRI guidance into the swine striatum. Thus, iMRI-guided RBD overcomes some of the technical limitations inherent to the use of straight cannulas and standard stereotactic targeting. This platform technology could have a major impact on the clinical translation of a wide range of cell therapeutics for the treatment of many neurological diseases.

Indexed as

Cell TransplantationAnimalsCadaverCatheterizationCorpus StriatumFemaleHumansMagnetic Resonance Imaging, InterventionalPutamenStereotaxic TechniquesSwine

Identifiers

PMID25138755
PMCPMC4426791
OpenAlexW1971514507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.