ArticleEnvironmental science and pollution research international2015
Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II).
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 47 citations in OpenAlex.
- How can simple household procedures reduce exposure to pesticides from fruits and vegetables: current habits and recommendations.Arhiv za higijenu rada i toksikologiju · 2025Article
- Associations of dichlorophenol with metabolic syndrome based on multivariate-adjusted logistic regression: a U.S. nationwide population-based study 2003-2016.Environmental health : a global access science source · 2023Article
- Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture.Nutrients · 2021Review
- Sex differences in the association of measures of sexual maturation to common toxicants: Lead, dichloro-diphenyl-trichloroethane (DDT), dichloro-diphenyl-dichloroethylene (DDE), and polychlorinated biphenyls (PCBs).Annals of human biology · 2021Review
- Association of urinary chlorophenols with central obesity in Korean girls.Environmental science and pollution research international · 2021Article
- Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men.Environment international · 2020Article
- Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health.Environmental science and pollution research international · 2018Article
- Associations of maternal exposure to triclosan, parabens, and other phenols with prenatal maternal and neonatal thyroid hormone levels.Environmental research · 2018Article
- Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study.Environment international · 2018Article
- Association of urinary concentrations of four chlorophenol pesticides with cardiometabolic risk factors and obesity in children and adolescents.Environmental science and pollution research international · 2018Article
- Human health implications of organic food and organic agriculture: a comprehensive review.Environmental health : a global access science source · 2017Review
- Phenol Concentrations During Childhood and Subsequent Measures of Adiposity Among Young Girls.American journal of epidemiology · 2017Article
- Associations between urinary concentrations of 2,5-dichlorophenol and metabolic syndrome among non-diabetic adults.Environmental science and pollution research international · 2016Article
- Thyroid nodules and thyroid autoimmunity in the context of environmental pollution.Reviews in endocrine & metabolic disorders · 2015Review
- The need for better management and control of POPs stockpiles.Environmental science and pollution research international · 2015Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the Flemish Environment and Health studies (FLEHS I, 2002-2006, and FLEHS II, 2007-2012), pesticide exposure, hormone levels and degree of sexual maturation were measured in 14-15-year-old adolescents residing in Flanders (Belgium). In FLEHS II, geometric mean concentrations (with 95 % confidence interval (CI)) of 307 (277-341) and 36.5 ng L(-1) (34.0-39.2) were found for p,p'-dichlorophenyldichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB). These values were respectively 26 and 60 % lower than levels in FLEHS I, 5 years earlier. Metabolites of organophosphorus pesticides (OPPs) and of para-dichlorobenzene were measured for the first time in FLEHS II, yielding concentrations of 11.4, 3.27 and 1.57 μg L(-1) for the sum of dimethyl- and diethyl phosphate metabolites and 2,5-dichlorophenol (2,5-DCP), respectively. Data on internal exposure of HCB showed a positive correlation with sexual maturation, testosterone and the aromatase index for boys and with free thyroxine (fT4) and thyroid stimulating hormone (TSH) (both boys and girls). For both p,p'-DDE and HCB, a negative association with sexual development in girls was found. The OPP metabolites were negatively associated with sex hormone levels in the blood of boys and with sexual maturation (both boys and girls). The pesticide metabolite 2,5-DCP was negatively correlated with free T4, while a positive association with TSH was reported (boys and girls). These results show that even exposure to relatively low concentrations of pesticides can have significant influences on hormone levels and the degree of sexual maturation in 14-15-year-old adolescents.
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