ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2014
Vitamin D and skeletal health in infancy and childhood.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pooled it
- Vitamin D status and adiposity in children with low-energy fractures: a prospective case-control study.European journal of pediatrics · 2026Observational
- BMI, Vitamin D Status, and Biochemical Markers of Mineralization in Children with Low-Energy Fractures: A Prospective Case-Control Study.Children (Basel, Switzerland) · 2026Article
- Does Vitamin D Concentration Matter? The Consequential Effects of Serum Vitamin D Concentration and Supplementation on Paediatric Fracture Risk.Nutrients · 2026Article
- The effect of vitamin D on the speed and quality of pediatric fracture healing.Journal of children's orthopaedics · 2025Article
- Vitamin D Levels During Fracture Healing in Children.Physiological research · 2024Article
- Longitudinal analysis of vitamin D levels considering sunshine duration and suggestion for a standardised approach for vitamin D supplementation in children and adolescents with obesity.BMC pediatrics · 2024Article
- Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023Review
- Influence of vitamin D supplementation on fracture risk, bone mineral density and bone biochemistry in Mongolian schoolchildren: multicenter double-blind randomized placebo-controlled trial.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children.The Journal of pediatrics · 2021Article
- Vitamin D Status in Children With Forearm Fractures: Incidence and Risk Factors.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2020Article
- Vitamin D, and Maternal and Child Health.Calcified tissue international · 2020Review
- The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength.Journal of bone and mineral metabolism · 2017Article
- Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture.Journal of endocrinological investigation · 2016Article
- The etiology and significance of fractures in infants and young children: a critical multidisciplinary review.Pediatric radiology · 2016Review
- Comparison of the Vitamin D Status of Children Younger and Older Than 2 Years in Tehran: Are Supplements Really Necessary?International journal of endocrinology and metabolism · 2016Article
- Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom.Bone · 2016Article
- Development, Epigenetics and Metabolic Programming.Nestle Nutrition Institute workshop series · 2016Review
- Life-course approach to nutrition.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed, rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review, we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however, there is evidence to suggest that vitamin D supplementation in children with the lowest levels of 25(OH)D might improve BMD. High-quality randomised trials are now required to confirm this benefit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.