Trial reportEuropean journal of heart failure2014
Impaired left atrial function in heart failure with preserved ejection fraction.
Trial report in European journal of heart failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00887588 (A 36-week, Randomized, Double-blind, Multi-center, Parallel Group, Active Controlled Study to Evaluate the Efficacy, Safety and Tolerability of LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction), which is not on this map. Cited by 116 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 36-week, Randomized, Double-blind, Multi-center, Parallel Group, Active Controlled Study to Evaluate the Efficacy, Safety and Tolerability of LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction
Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 252 citations in OpenAlex.
- Left atrial structure and function in heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF): systematic review and meta-analysis.Heart failure reviews · 2022Pooled it
- Diagnostic value of echocardiographic markers for diastolic dysfunction and heart failure with preserved ejection fraction.Heart failure reviews · 2022Pooled it
- Extended-Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2020Trial
- Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure · 2016Trial
- Right Atrial Function in Pulmonary Arterial Hypertension.Circulation. Cardiovascular imaging · 2015Trial
- Beyond E/e': A Physiology-Based Framework for Emerging Echocardiographic Biomarkers in the Noninvasive Assessment of Left Ventricular Filling Pressure.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Usefulness of Strain Echocardiography in Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2026Review
- Article
- Echocardiographic Phenomapping in HFpEF: From Imaging Biomarkers to Precision Cardiovascular Medicine.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Baseline remodeling-dependent changes in left atrial strain after catheter ablation for paroxysmal atrial fibrillation.Journal of echocardiography · 2026Article
- Relationship between epicardial adipose tissue and left atrial stiffness estimated from echocardiographic parameters and left atrial pressure in patients with atrial fibrillation.Heart and vessels · 2026Article
- Impaired left atrial function increases the risk of incident atrial fibrillation and heart failure with preserved ejection fraction in hypertensive patients.BMC cardiovascular disorders · 2026Article
- Role of imaging techniques in monitoring atrial cardiomyopathy and atrial failure: a scientific statement.ESC heart failure · 2026Review
- Uncoupling of energy metabolism and myocardial function in early left atrial dysfunction: a metabolomics study.Frontiers in cardiovascular medicine · 2026Article
- Comparative analysis of myocardial strain parameters in acute decompensated heart failure phenotypes: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction?Journal of the American College of Cardiology · 2025Review
- Clinical Applications of Speckle-Tracking Echocardiography in Heart Failure: From Diagnosis to Prognostication.International journal of heart failure · 2025Review
- Early detection of left atrial function alterations across the heart failure spectrum by feature tracking-cardiac magnetic resonance.European radiology · 2025Article
- The left atrium in heart failure with preserved ejection fraction: What we know and what we do not know.Heart rhythm O2 · 2025Review
- Early Echocardiographic Markers in Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular development and disease · 2025Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 6 countries.
Funding
Abstract
aimsLeft atrial (LA) enlargement is present in the majority of heart failure with preserved ejection fraction (HFpEF) patients and is a marker of risk. However, the importance of LA function in HFpEF is less well understood. METHODS AND
resultsThe PARAMOUNT trial enrolled HFpEF patients (LVEF ≥45%, NT-proBNP >400 pg/mL). We assessed LA reservoir, conduit, and pump function using two-dimensional volume indices and speckle tracking echocardiography in 135 HFpEF patients in sinus rhythm at the time of echocardiography and 40 healthy controls of similar age and gender. Systolic LA strain was related to clinical characteristics and measures of cardiac structure and function. Compared with controls, HFpEF patients had worse LA reservoir, conduit, and pump function. The differences in systolic LA strain (controls 39.2 ± 6.6% vs. HFpEF 24.6 ± 7.3%) between groups remained significant after adjustments and even in the subsets of HFpEF patients with normal LA size or without a history of AF. Among HFpEF patients, lower systolic LA strain was associated with higher prevalence of prior HF hospitalization and history of AF, as well as worse LV systolic function, and higher LV mass and LA volume. However, NT-proBNP and E/E' were similar across the quartiles of LA function.
conclusionsIn this HFpEF cohort, we observed impairment in all phases of LA function, and systolic LA strain was decreased independent of LA size or history of AF. LA dysfunction may be a marker of severity and play a pathophysiological role in HFpEF.
trial registrationNCT00887588.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.