ArticleIntensive care medicine2014
Secretoneurin as a marker for hypoxic brain injury after cardiopulmonary resuscitation.
Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Serum secretoneurin as a promising biomarker for predicting poor prognosis in intracerebral hemorrhage: A prospective cohort study.Neurosurgical review · 2024Article
- Clinical Value of Serum Secretoneurin Levels in Prediction of Delayed Cerebral Ischemia and Prognostic Analysis of Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.International journal of general medicine · 2024Article
- Predictive Performance of Neuron-Specific Enolase (NSE) for Survival after Resuscitation from Cardiac Arrest: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Evaluation of Serum Secretoneurin Levels in Patients With Ischemic Stroke Who Underwent Mechanical Thrombectomy.Cureus · 2023Article
- Investigation of secretoneurin as a potential biomarker of brain injury in very preterm infants: A pilot study.PloS one · 2023Article
- Postresuscitation care and prognostication after cardiac arrest-Does sex matter?Wiener klinische Wochenschrift · 2022Observational
- Increased risk of ventilator-associated pneumonia in patients after cardiac arrest treated with mild therapeutic hypothermia.Acta anaesthesiologica Scandinavica · 2022Observational
- Blood-brain barrier disruption as a cause of various serum neuron-specific enolase cut-off values for neurological prognosis in cardiac arrest patients.Scientific reports · 2022Article
- The Role of Serum Secretoneurin Levels in Patients with Traumatic Brain Injury.Current neurovascular research · 2022Article
- Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest.Annals of intensive care · 2019Article
- Non-Coding RNAs to Aid in Neurological Prognosis after Cardiac Arrest.Non-coding RNA · 2018Review
- Acute kidney injury and mild therapeutic hypothermia in patients after cardiopulmonary resuscitation - a post hoc analysis of a prospective observational trial.Critical care (London, England) · 2018Observational
- Secretoneurin A Directly Regulates the Proteome of Goldfish Radial Glial CellsFrontiers in endocrinology · 2018Article
- Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure.Current heart failure reports · 2017Review
- Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia.Scientific reports · 2017Article
- Secretoneurin as a novel predictor of metabolic syndrome in patients with obstructive sleep apnea syndrome.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe neuropeptide secretoneurin (SN) shows widespread distribution in the brain. We evaluated whether SN is elevated after cardiopulmonary resuscitation (CPR) and could serve as a potential new biomarker for hypoxic brain injury after CPR.
methodsThis was a prospective observational clinical study. All patients admitted to a tertiary medical intensive care unit after successful CPR with expected survival of at least 24 h were consecutively enrolled from September 2008 to April 2013. Serum SN and neuron-specific enolase were determined in 24 h intervals starting with the day of CPR for 7 days. Neurological outcome was assessed with the Cerebral Performance Categories Scale (CPC) at hospital discharge.
resultsA total of 134 patients were included with 49 % surviving to good neurological outcome (CPC 1-2). SN serum levels peaked within the first 24 h showing on average a sixfold increase above normal. SN levels were significantly higher in patients with poor (CPC 3-5) than in patients with good neurological outcome [0-24 h: 75 (43-111) vs. 38 (23-68) fmol/ml, p < 0.001; 24-48 h: 45 (24-77) vs. 23 (16-39) fmol/ml, p < 0.001]. SN determined within the first 48 h showed a receiver operating characteristic (ROC) area under the curve (AUC) of 0.753 (0.665-0.841). NSE in the first 72 h had a ROC-AUC of 0.881 (0.815-0.946). When combining the two biomarkers an AUC of 0.925 (0.878-0.972) for outcome prediction could be reached.
conclusionsSN is a promising early biomarker for hypoxic brain injury. Further studies will be required for confirmation of these results.
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