ArticleThe Journal of clinical endocrinology and metabolism2014
Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Role ofInternational journal of molecular sciences · 2026Article
- A polygenic growth score and risk for large for gestational age birth weight.Journal of the Endocrine Society · 2026Article
- Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study.medRxiv : the preprint server for health sciences · 2025Article
- Association Between Carbohydrate Quality Index During Pregnancy and Risk for Large-for-Gestational-Age Neonates: Results from the BORN 2020 Study.Children (Basel, Switzerland) · 2025Article
- The Effect of Maternal Race, Ethnicity, and Nativity on Macrosomia Among Infants Born in the United States.Cureus · 2023Article
- Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies.PLoS genetics · 2020Article
- Relative Contribution of Gestational Weight Gain, Gestational Diabetes, and Maternal Obesity to Neonatal Fat Mass.Nutrients · 2020Article
- Gene coexpression network analysis identified potential biomarkers in gestational diabetes mellitus progression.Molecular genetics & genomic medicine · 2019Article
- AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.International journal of epidemiology · 2018Article
- Influence of Fetal and Maternal Genetic Susceptibility to Obesity on Birthweight in African Ancestry Populations.Frontiers in genetics · 2018Article
- Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.BMC medicine · 2017Article
- Genome-wide association study of body mass index in subjects with alcohol dependence.Addiction biology · 2017Article
- Article
- Excessive gestational weight gain in the first trimester among women with normal glucose tolerance and resulting neonatal adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
contextMacrosomic infants are at increased risk for adverse metabolic outcomes. Improving prediction of large-for-gestational-age (LGA) birth may help prevent these outcomes.
objectiveThis study sought to determine whether genes associated with obesity-related traits in adults are associated with newborn size, and whether a genetic risk score (GRS) predicts LGA birth. SETTING AND
designSingle nucleotide polymorphisms (SNPs) in 40 regions associated with adult obesity-related traits were tested for association with newborn size. GRS's for birth weight and sum of skinfolds (SSF) specific to ancestry were calculated using the most highly associated SNP for each ancestry in genomic regions with one or more SNPs associated with birth weight and/or SSF in at least one ancestry group or meta-analyses.
participantsNewborns from the Hyperglycemia Adverse Pregnancy Outcomes Study were studied (942 Afro-Caribbean, 1294 Northern European, 573 Mexican-American, and 1182 Thai). OUTCOME MEASURES: Birth weight >90th percentile (LGA) and newborn SSF >90th percentile were primary outcomes.
resultsAfter adjustment for ancestry, sex, gestational age at delivery, parity, maternal genotype, maternal smoking/alcohol intake, age, body mass index, height, blood pressure and glucose, 25 and 23 SNPs were associated (P < .001) with birth weight and newborn SSF, respectively. The GRS was highly associated with both phenotypes as continuous variables across all ancestries (P ≤ 1.6 × 10(-19)) and improved prediction of birth weight and SSF >90th percentile when added to a baseline model incorporating the covariates listed above.
conclusionsA GRS comprised of SNPs associated with adult obesity-related traits may provide an approach for predicting LGA birth and newborn adiposity beyond established risk factors.
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