Evidence map›Paper›PMID 25137290›Full record

ArticleChemical communications (Cambridge, England)2014

A multimeric MR-optical contrast agent for multimodal imaging.

Victoria S R Harrison, Christiane E Carney, Keith W Macrenaris, Thomas J Meade

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Magnetic barcode imaging for contrast agents.Magnetic resonance in medicine · 2017
    Article
  9. Review
  10. Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging.Journal of the American Chemical Society · 2015
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Victoria S R HarrisonDepartment of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA. tmeade@u.northwestern.edu.
Christiane E Carney
Keith W Macrenaris
Thomas J Meade
Institute of Neurobiology · BGNorthwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
q-Modulated Magnetic Resonance Imaging Contrast AgentsR01EB005866 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2005 to 2013
$2.2M
Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine DiseaseR01EB014806 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2012 to 2015
$1.4M
NCI NIH HHS P30 CA060553NIBIB NIH HHS R01 EB005866NIBIB NIH HHS R01EB005866NIBIB NIH HHS R01 EB014806
6 · The paper itself

Abstract

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

Indexed as

Magnetic Resonance ImagingAnimalsCell Line, TumorChelating AgentsContrast MediaCoordination ComplexesFluorescent DyesGadoliniumHeLa CellsHumansMiceMicroscopy, ConfocalOptical ImagingChelating AgentsContrast MediaCoordination ComplexesFluorescent DyesGadolinium

Identifiers

PMID25137290
PMCPMC4344311
OpenAlexW2079965218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.