SynthesisPloS one2014
Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 8 syntheses or guidelines pooled it, 205 citations in OpenAlex.
- Global mortality of glaucoma: a systematic review and meta-analysis of prospective studies.International ophthalmology · 2026Pooled it
- Tobacco smoking is not associated with primary open-angle glaucoma: a systematic review and meta-analysis.International ophthalmology · 2026Pooled it
- Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.Eye (London, England) · 2022Pooled it
- Association between glaucoma and risk of stroke: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Pooled it
- The effect of diabetes on corneal endothelium: a meta-analysis.BMC ophthalmology · 2021Pooled it
- Triglycerides and Open Angle Glaucoma - A Meta-analysis with meta-regression.Scientific reports · 2017Pooled it
- Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study.Scientific reports · 2018Trial
- Retinal oxygen saturation and retinal vessel diameter in glaucoma patients before and after trabeculectomy.Acta ophthalmologica · 2026Article
- Fundus Stretch Index: A Centile-Based Retinal Measure of Myopia.Ophthalmology science · 2026Article
- Complications of minimally invasive surgery for primary open-angle glaucoma in patients with diabetic retinopathy: a retrospective cohort study.International ophthalmology · 2026Article
- Hydrochlorothiazide and chlorthalidone use and glaucoma risk: pharmacovigilance analysis and nationwide cohort study.Frontiers in pharmacology · 2026Article
- Prevalence and Risk Factors of Open-Angle Glaucoma in an Adult Chinese American Population: The Chinese American Eye Study.American journal of ophthalmology · 2025Article
- Spatiotemporal trend of sensory impairments in China and its provinces from 2011 to 2018: insights from CHARLS.BMC public health · 2025Article
- Intraocular pressure variation (ocular hypertension) in diabetes mellitus.World journal of clinical cases · 2025Review
- Higher risk and earlier onset glaucoma in Cushing's syndrome.Acta ophthalmologica · 2025Article
- Association of stage of diabetic retinopathy on intraocular pressure.Digital journal of ophthalmology : DJO · 2025Article
- Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer's disease: a large cohort study in UK biobank.Frontiers in endocrinology · 2025Article
- The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review.Biomedicines · 2024Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the association between diabetes mellitus (DM) and primary open-angle glaucoma (POAG).
methodsThis is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases (PubMed and Embase) and the reference lists of the retrieved studies. Separate meta-analyses for case-control studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and relative risks (RRs), respectively.
resultsThirteen studies--seven case-control studies and six population-based cohort studies--were included in this meta-analysis. The pooled RR of the association between DM and POAG based on the risk estimates of the six cohort studies was 1.40 (95% CI, 1.25-1.57). The pooled OR of the association between DM and POAG based on the risk estimates of the seven case-control studies was 1.49 (95% CI, 1.17-1.88). There was considerable heterogeneity among the case-control studies that reported an association between DM mellitus and POAG (P<0.001) and no significant heterogeneity among the cohort studies (P = 0.377). After omitting the case-control study that contributed significantly to the heterogeneity, the pooled OR for the association between DM and POAG was 1.35 (95% CI, 1.06-1.74).
conclusionsIndividuals with DM have an increased risk of developing POAG.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.