Evidence map›Paper›PMID 25137019›Full record

ArticleBritish journal of cancer2014

Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers.

T Kantola, J P Väyrynen, K Klintrup, J Mäkelä, S M Karppinen, T Pihlajaniemi, H Autio-Harmainen, T J Karttunen, M J Mäkinen, A Tuomisto

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Article
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  7. Article
  8. Article
  9. Endostatin in Renal and Cardiovascular Diseases.Kidney diseases (Basel, Switzerland) · 2021
    Review
  10. Extracellular Matrix Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Review
  13. Review
  14. Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

T Kantola1] Department of Pathology, University of Oulu, POB 5000, 90014 Oulu, Finland [2] Oulu University Hospital, POB 21, 90029 Oulu, Finland [3] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
J P Väyrynen1] Department of Pathology, University of Oulu, POB 5000, 90014 Oulu, Finland [2] Oulu University Hospital, POB 21, 90029 Oulu, Finland [3] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
K Klintrup1] Oulu University Hospital, POB 21, 90029 Oulu, Finland [2] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland [3] Department of Surgery, University of Oulu, POB 5000, 90014 Oulu, Finland.
J Mäkelä1] Oulu University Hospital, POB 21, 90029 Oulu, Finland [2] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland [3] Department of Surgery, University of Oulu, POB 5000, 90014 Oulu, Finland.
S M KarppinenFaculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, POB 5400, 90014 Oulu, Finland.
T PihlajaniemiFaculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, POB 5400, 90014 Oulu, Finland.
H Autio-Harmainen1] Department of Pathology, University of Oulu, POB 5000, 90014 Oulu, Finland [2] Oulu University Hospital, POB 21, 90029 Oulu, Finland [3] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
T J Karttunen1] Department of Pathology, University of Oulu, POB 5000, 90014 Oulu, Finland [2] Oulu University Hospital, POB 21, 90029 Oulu, Finland [3] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
M J Mäkinen1] Department of Pathology, University of Oulu, POB 5000, 90014 Oulu, Finland [2] Oulu University Hospital, POB 21, 90029 Oulu, Finland [3] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
A Tuomisto1] Department of Pathology, University of Oulu, POB 5000, 90014 Oulu, Finland [2] Oulu University Hospital, POB 21, 90029 Oulu, Finland [3] Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
University of Oulu · FIOulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndostatin, a fragment of collagen XVIII, is an endogenous angiogenesis inhibitor with anti-tumour functions. However, elevated circulating endostatin concentrations have been found in several human cancers including colorectal cancer (CRC).

methodsSerum endostatin levels were measured by enzyme-linked immunoassay from a series of 143 patients with CRC and from 84 controls, and correlated with detailed clinicopathological features of CRC, serum leukocyte differential count and C-reactive protein (CRP) levels.

resultsPatients with CRC had higher serum endostatin levels than the controls (P=0.005), and high levels associated with age, tumour invasion through the muscularis propria and poor differentiation, but not with metastases. Endostatin levels showed a positive correlation with the markers of systemic inflammatory response and a negative correlation with the densities of tumour-infiltrating mast cells and dendritic cells. Collagen XVIII was expressed in tumour stroma most strikingly in blood vessels and capillaries, and in the muscle layer of the bowel wall.

conclusionsElevated endostatin levels in CRC correlate with systemic inflammation and invasion through the muscularis propria. Increased endostatin level may be a result of invasion-related cleavage of collagen XVIII expressed in the bowel wall. The negative correlations between serum endostatin and intratumoural mast cells and immature dendritic cells may reflect angiogenesis inhibition by endostatin.

Indexed as

Neoplasm InvasivenessAgedBiomarkers, TumorCollagen Type XVIIIColorectal NeoplasmsEndostatinsFemaleHumansInflammationMaleMiddle AgedBiomarkers, TumorCollagen Type XVIIIEndostatins

Identifiers

PMID25137019
PMCPMC4200096
OpenAlexW1976762025

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.