Evidence map›Paper›PMID 25136825›Full record

ArticlePloS one2014

Deep brain stimulation of the antero-medial globus pallidus interna for Tourette syndrome.

Perminder S Sachdev, Adith Mohan, Elisabeth Cannon, John D Crawford, Paul Silberstein, Raymond Cook, Terrence Coyne, Peter A Silburn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Deep brain stimulation for Tourette's syndrome.Translational neurodegeneration · 2020
    Review
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  14. Deep brain stimulation in Tourette's syndrome: evidence to date.Neuropsychiatric disease and treatment · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Perminder S SachdevNeuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia; Centre for Healthy Brain Ageing, School of Psychiatry, The University of New South Wales, Sydney, Australia.
Adith MohanNeuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia; Centre for Healthy Brain Ageing, School of Psychiatry, The University of New South Wales, Sydney, Australia.
Elisabeth CannonNeuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
John D CrawfordCentre for Healthy Brain Ageing, School of Psychiatry, The University of New South Wales, Sydney, Australia.
Paul SilbersteinNorth Shore Private Hospital, St. Leonards, Sydney, NSW, Australia.
Raymond CookNorth Shore Private Hospital, St. Leonards, Sydney, NSW, Australia.
Terrence CoyneCentre for Clinical Research, University of Queensland, Herston, QLD, Australia; St. Andrew's War Memorial Hospital, Spring Hill, QLD, Australia.
Peter A SilburnCentre for Clinical Research, University of Queensland, Herston, QLD, Australia; St. Andrew's War Memorial Hospital, Spring Hill, QLD, Australia.
Prince of Wales Hospital · AURoyal North Shore Hospital · AUSt Andrew’s Hospital · AUUniversity of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe have previously reported the results of Deep Brain Stimulation (DBS) of the antero-medial globus pallidus interna (GPi) for severe Tourette Syndrome (TS) in 11 patients. We extend this case series to 17 patients and a longer follow-up to a maximum of 46 months.

methods17 patients (14 male; mean age 29.1 years, range 17-51 years) with severe and medically intractable TS were implanted with Medtronic quadripolar electrodes bilaterally in the antero-medial GPi. The primary outcome measure was the Yale Global Tic Severity Scale (YGTSS). Secondary outcome measures included the Yale-Brown Obsessive Compulsive Scale, Hamilton Depression Rating Scale, Gilles de la Tourette Quality of Life Scale and Global Assessment of Functioning. Follow up was at one month, three months and finally at a mean 24.1 months (range 8-46 months) following surgery.

resultsOverall, there was a 48.3% reduction in motor tics and a 41.3% reduction in phonic tics at one month, and this improvement was maintained at final follow-up. 12 out of 17 (70.6%) patients had a>50% reduction in YGTSS score at final follow up. Only 8 patients required ongoing pharmacotherapy for tics post-surgery. Patients improved significantly on all secondary measures. Adverse consequences included lead breakage in 4 patients, infection (1), transient anxiety (2), dizziness (1), poor balance (1) and worsening of stuttering (1).

conclusionsThis case series provides further support that antero-medial GPi DBS is an effective and well tolerated treatment for a subgroup of severe TS, with benefits sustained up to 4 years.

Indexed as

AdolescentAdultDeep Brain StimulationFemaleGlobus PallidusHumansMaleMiddle AgedTourette SyndromeTreatment OutcomeYoung Adult

Identifiers

PMID25136825
PMCPMC4138156
OpenAlexW2146291422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.