Evidence map›Paper›PMID 25136695›Full record

ArticleTheScientificWorldJournal2014

PLUNC proteins positivity in patients with chronic rhinosinusitis: a case-control study.

Desiderio Passali, Codrut Sarafoleanu, Claudiu Manea, Michele Loglisci, Francesco Maria Passali, Jacopo Cambi, Cristina Iosif, Eugenia Panaitescu, Luisa Maria Bellussi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Desiderio PassaliDirettore Otorinolaringoiatria, Azienda Ospedaliera Universitaria Senese, Viale Bracci, 53100 Siena, Italy.
Codrut SarafoleanuENT Department, Sfanta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy 37, Dionisie Lupu Street, 020021 Bucharest, Romania.ORCID 0000-0002-9436-7772
Claudiu ManeaENT Department, Sfanta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy 37, Dionisie Lupu Street, 020021 Bucharest, Romania.ORCID 0000-0002-7125-293X
Michele LoglisciDirettore Otorinolaringoiatria, Azienda Ospedaliera Universitaria Senese, Viale Bracci, 53100 Siena, Italy.
Francesco Maria PassaliENT Department, Univeristá degli Studi "Tor Vergata" di Roma, U.O.C. di Otorinolaringoiatria, Viale Oxford 81, 00133 Rome, Italy.
Jacopo CambiDirettore Otorinolaringoiatria, Azienda Ospedaliera Universitaria Senese, Viale Bracci, 53100 Siena, Italy.
Cristina IosifAnatomopathology Department, Sfanta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy 37, Dionisie Lupu Street, 020021 Bucharest, Romania.
Eugenia PanaitescuDepartment of Medical Informatics and Biostatistics, Sfanta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy 37, Dionisie Lupu Street, 020021 Bucharest, Romania.ORCID 0000-0002-0083-8992
Luisa Maria BellussiDirettore Otorinolaringoiatria, Azienda Ospedaliera Universitaria Senese, Viale Bracci, 53100 Siena, Italy.
Azienda Ospedaliera Universitaria Senese · ITCarol Davila University of Medicine and Pharmacy · ROUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInnate immunity is the first protection against microorganisms. Nowadays, there is a growing interest in innate immune molecule known as palate, lung, nasal epithelial clone (PLUNC). PLUNC is a specific product of the airways, of approximately 25 kDa, encoded by adjacent genes found within a 300 kb region of chromosome 20; these proteins must be detected predominantly in the upper respiratory tract. MATERIALS AND

methodsWe performed a case-control study to investigate the presence of this protein in nasal tissue of patients affected by chronic rhinosinusitis. 59 patients were enrolled (44 cases, 15 controls). We have examined the correlation between the presence of pathology and the PLUNC proteins positivity.

results100% of controls have a +++ rated PLUNC proteins positivity, while cases have a lower percentage of positivity. We used χ (2) statistical test to analyze the results of the study and there is a difference statistically significant between cases and controls in PLUNC proteins positivity.

conclusionsThese observations suggest that, in response to agents or chemical factors, nasal mucosal epithelium will react and produce PLUNC proteins. So PLUNC proteins have a protective function on upper airways mucosa, as we can see by evaluating the high positivity in control group.

Indexed as

AdultAgedCase-Control StudiesFemaleGlycoproteinsHumansMaleMiddle AgedPhosphoproteinsRhinitisSinusitisYoung AdultBPIFA1 protein, humanGlycoproteinsPhosphoproteins

Identifiers

PMID25136695
PMCPMC4124241
OpenAlexW2169787100

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.