Evidence map›Paper›PMID 25136615›Full record

ArticleBioMed research international2014

Human endogenous retrovirus W activity in cartilage of osteoarthritis patients.

Signy Bendiksen, Inigo Martinez-Zubiavrra, Conny Tümmler, Gunnar Knutsen, Jan Elvenes, Elisabeth Olsen, Randi Olsen, Ugo Moens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Molecular functions of human endogenous retroviruses in health and disease.Cellular and molecular life sciences : CMLS · 2015
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Signy BendiksenDepartment of Laboratory Medicine, University Hospital of North Norway, Sykehusveien 38, 9038 Tromsø, Norway.
Inigo Martinez-ZubiavrraDepartment of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, MH-Building, 9037 Tromsø, Norway.
Conny TümmlerGenøk Centre of Biosafety, Science Park, Sykehusveien 23, 9294 Tromsø, Norway.ORCID 0000-0002-5530-4752
Gunnar KnutsenDepartment of Orthopaedics, University Hospital of North Norway, Sykehusveien 38, 3098 Tromsø, Norway.
Jan ElvenesDepartment of Orthopaedics, University Hospital of North Norway, Sykehusveien 38, 3098 Tromsø, Norway.
Elisabeth OlsenGenøk Centre of Biosafety, Science Park, Sykehusveien 23, 9294 Tromsø, Norway.
Randi OlsenDepartment of Electron Microscopy, Institute of Medical Biology, Faculty of Health Sciences, University of Tromsø, Sykehusveien 44, 9037 Tromsø, Norway.
Ugo MoensDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, MH-Building, 9037 Tromsø, Norway.ORCID 0000-0002-1931-5462
UiT The Arctic University of Norway · NOUniversity Hospital of North Norway · NOGenØk · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology of viruses in osteoarthritis remains controversial because the prevalence of viral nucleic acid sequences in peripheral blood or synovial fluid from osteoarthritis patients and that in healthy control subjects are similar. Until now the presence of virus has not been analyzed in cartilage. We screened cartilage and chondrocytes from advanced and non-/early osteoarthritis patients for parvovirus B19, herpes simplex virus-1, Epstein Barr virus, cytomegalovirus, human herpes virus-6, hepatitis C virus, and human endogenous retroviruses transcripts. Endogenous retroviruses transcripts, but none of the other viruses, were detected in 15 out the 17 patients. Sequencing identified the virus as HERV-WE1 and E2. HERV-W activity was confirmed by high expression levels of syncytin, dsRNA, virus budding, and the presence of virus-like particles in all advanced osteoarthritis cartilages examined. Low levels of HERV-WE1, but not E2 envelope RNA, were observed in 3 out of 8 non-/early osteoarthritis patients, while only 3 out of 7 chondrocytes cultures displayed low levels of syncytin, and just one was positive for virus-like particles. This study demonstrates for the first time activation of HERV-W in cartilage of osteoarthritis patients; however, a causative role for HERV-W in development or deterioration of the disease remains to be proven.

Indexed as

AdultAgedAged, 80 and overCartilageChondrocytesEndogenous RetrovirusesFemaleGene Products, envHumansMaleMiddle AgedOsteoarthritisPregnancy ProteinsRNA, Double-StrandedSynovial FluidGene Products, envPregnancy ProteinsRNA, Double-Strandedsyncytin

Identifiers

PMID25136615
PMCPMC4130134
OpenAlexW2045148364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.