Evidence map›Paper›PMID 25136563›Full record

ArticleBioMed research international2014

Effects of parity and serum prolactin levels on the incidence and regression of DMBA-induced tumors in OFA hr/hr rats.

Corina V Sasso, Flavia E Santiano, Constanza M López-Fontana, Virginia Pistone-Creydt, Marcelo E Ezquer, María B Hapon, Graciela A Jahn, Rubén W Carón

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Corina V SassoLaboratory of Hormones and Biology of Cancer, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, CCT-Mendoza, Avenida Adrián Ruiz-Leal s/n, CC855, 5500 Mendoza, Argentina.ORCID 0000-0003-4127-2902
Flavia E SantianoLaboratory of Hormones and Biology of Cancer, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, CCT-Mendoza, Avenida Adrián Ruiz-Leal s/n, CC855, 5500 Mendoza, Argentina.ORCID 0000-0001-5607-156X
Constanza M López-FontanaLaboratory of Hormones and Biology of Cancer, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, CCT-Mendoza, Avenida Adrián Ruiz-Leal s/n, CC855, 5500 Mendoza, Argentina.
Virginia Pistone-CreydtLaboratory of Hormones and Biology of Cancer, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, CCT-Mendoza, Avenida Adrián Ruiz-Leal s/n, CC855, 5500 Mendoza, Argentina.ORCID 0000-0002-1079-4663
Marcelo E EzquerInstitute of Sciences, Faculty of Medicine, German Clinique, University of Development, Santiago, Chile.
María B HaponLaboratory of Reproduction and Lactation, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, 5500 Mendoza, Argentina.ORCID 0000-0003-4381-5368
Graciela A JahnLaboratory of Reproduction and Lactation, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, 5500 Mendoza, Argentina.
Rubén W CarónLaboratory of Hormones and Biology of Cancer, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), CONICET, CCT-Mendoza, Avenida Adrián Ruiz-Leal s/n, CC855, 5500 Mendoza, Argentina.ORCID 0000-0002-8223-9140
Consejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Medicina y Biología Experimental de Cuyo · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol). The tumor incidence was similar in the three groups. However, a higher percentage of regressing tumors was evident in the PL group. Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null. The expression of hormone receptors was similar in the different groups. However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors. Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains. However, supraphysiological levels of PRL affect carcinogenesis. PL induces regression of the tumors due to the differentiation produced on the mammary cells. Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors.

Indexed as

Mammary Glands, AnimalMammary Neoplasms, ExperimentalParity9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogensFemaleNeoplasm ProteinsPregnancyProlactinRats9,10-Dimethyl-1,2-benzanthraceneCarcinogensNeoplasm ProteinsProlactin

Identifiers

PMID25136563
PMCPMC4124788
OpenAlexW2029386487

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.