Evidence map›Paper›PMID 25136552›Full record

Trial reportBioMed research international2014

Alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study.

Salvatore Sansalone, Rosario Leonardi, Gabriele Antonini, Antonio Vitarelli, Giuseppe Vespasiani, Dragoslav Basic, Giuseppe Morgia, Sebastiano Cimino, Giorgio Ivan Russo

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effects of Tribulus (Nutrients · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Salvatore SansaloneDepartment of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
Rosario LeonardiCentro Uro Andrologico, Acireale, Italy.
Gabriele AntoniniDepartment of Urology "U. Bracci", La Sapienza University of Rome, Rome, Italy.
Antonio VitarelliUrologia Universitaria II, Azienda Ospedaliera Policlinico Bari, Bari, Italy.
Giuseppe VespasianiDepartment of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
Dragoslav BasicClinic of Urology, Clinical Center Nis, Nis, Serbia.ORCID 0000-0001-8746-960X
Giuseppe MorgiaSchool of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, Italy.ORCID 0000-0002-7224-7577
Sebastiano CiminoSchool of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, Italy.ORCID 0000-0002-6045-3373
Giorgio Ivan RussoSchool of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, Italy.ORCID 0000-0003-4687-7353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to evaluate the efficacy of oral therapy with alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide (Tradamix TX1000) in patients with erectile dysfunction (ED) at 3 months of follow-up. From January 2013 to September 2013, 177 patients diagnosed with mild-moderate ED (IIEF-EF < 26) were enrolled in this multicenter, single-blinded, placebo-controlled study and randomized in Group A (Tradamix, n = 87) and Group B (placebo, n = 90). Penile color Doppler ultrasound measures, IIEF-15 questionnaire, male sexual health questionnaire-ejaculation disorder (MSHQ-EjD), and sexual quality of life (SQoL-M) were collected. We observed significant changes of the IIEF-15 in Group A (mean difference: 11.54; P < 0.05) at 3 months versus Group B (P < 0.05). PSV (P < 0.05), IIEF-intercourse satisfaction (P < 0.05), IIEF-orgasmic function (mean P < 0.05), IIEF-sexual desire (P < 0.05), IIEF-overall satisfaction (P < 0.05), MSHQ-EjD (mean difference: 1.21; P < 0.05), and SQoL-M (mean difference: 10.2; P < 0.05) were significantly changed in Group A versus baseline and Group B. Patients with moderate arterial dysfunction showed significant increase of PSV (P < 0.05), IIEF-EF (P < 0.05), MSHQ-EjD (P < 0.05), and SQoL-M (P < 0.05) in Group A. Therapy with Tradamix improves erectile and ejaculation function and sexual quality of life in patients with mild-moderate ED and in particular for those with moderate arterial dysfunction.

Indexed as

Erectile DysfunctionTribulusAgedEjaculationGlucosamineHumansMaleMiddle AgedOligosaccharidesPenile ErectionPhytotherapyProspective StudiesRecovery of FunctionGlucosamineOligosaccharides

Identifiers

PMID25136552
PMCPMC4127274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.