Evidence map›Paper›PMID 25136550›Full record

Trial reportBioMed research international2014

Effects of a pragmatic lifestyle intervention for reducing body mass in obese adults with obstructive sleep apnoea: a randomised controlled trial.

James Moss, Garry Alan Tew, Robert James Copeland, Martin Stout, Catherine Grant Billings, John Michael Saxton, Edward Mitchell Winter, Stephen Mark Bianchi

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01546792 (Effects of a Lifestyle Intervention on Quality of Life, Weight Loss and Cardiovascular Risk in Patients With Obstructive Sleep Apnoea Established on Continuous Positive Airway Pressure), which is not on this map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01546792 phase2 / phase3completednot on this map

Effects of a Lifestyle Intervention on Quality of Life, Weight Loss and Cardiovascular Risk in Patients With Obstructive Sleep Apnoea Established on Continuous Positive Airway Pressure

TypeinterventionalSponsorSheffield Teaching Hospitals NHS Foundation TrustRan2010 to 2011Enrolled60ConditionsObstructive Sleep Apnoea, ObesityArmsCombined lifestyle intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

James MossThe Farr Institute of Health Informatics, Department of Epidemiology and Public Health, University College London, 222 Euston Road, London NW1 2DA, UK.ORCID 0000-0002-3916-1982
Garry Alan TewYork Trials Unit, University of York, Heslington, York YO10 5DD, UK.
Robert James CopelandCentre for Sport and Exercise Science, Sheffield Hallam University, Sheffield S10 2BP, UK.
Martin StoutNorth West Heart Centre, Wythenshawe Hospital, University Hospital of South Manchester, Southmoor Road, Manchester M23 9LT, UK.
Catherine Grant BillingsAcademic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals Foundation Trust, Sheffield S5 7AU, UK.
John Michael SaxtonSchool of Health Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.
Edward Mitchell WinterCentre for Sport and Exercise Science, Sheffield Hallam University, Sheffield S10 2BP, UK.
Stephen Mark BianchiAcademic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals Foundation Trust, Sheffield S5 7AU, UK.
Sheffield Hallam University · GBSheffield Teaching Hospitals NHS Foundation Trust · GBFarr Institute · GBUniversity of East Anglia · GBUniversity of York · GBWythenshawe Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (-1.8 [-3.0, -0.5] kg; P = 0.007) and body fat percentage (-1 [-2, 0]%; P = 0.044) and moderate improvements in C-reactive protein (-1.3 [-2.4, -0.2] mg·L(-1); P = 0.028) and exercise capacity (95 [50, 139] m; P < 0.001). At follow-up, changes in body mass (-2.0 [-3.5, -0.5] kg; P = 0.010), body fat percentage (-1 [-2, 0]%; P = 0.033), and C-reactive protein (-1.3 [-2.5, -0.1] mg·L(-1); P = 0.037) were maintained and exercise capacity was further improved (132 [90, 175] m; P < 0.001). This trial is registered with ClinicalTrials.gov NCT01546792.

Indexed as

Body Mass IndexLife StyleObesitySleep Apnea, ObstructiveAdolescentAdultCognitive Behavioral TherapyDietExercise TherapyFemaleHumansMaleMiddle AgedTime Factors

Identifiers

PMID25136550
PMCPMC4127266
OpenAlexW2053447916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.