ArticleBiomedical optics express2014
Direct observation and validation of fluorescein tear film break-up patterns by using a dual thermal-fluorescent imaging system.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Improvements in Image Registration, Segmentation, and Artifact Removal in ThermOcular Imaging System.Journal of imaging · 2025Article
- Comparing the corneal temperature of dry eyes with that of normal eyes via high-resolution infrared thermography.Frontiers in medicine · 2024Article
- Comparing the ocular surface temperature and dry eye condition of keratoconus with normal eyes using infrared thermal imaging.International ophthalmology · 2023Article
- Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease.Diagnostics (Basel, Switzerland) · 2020Review
- Mathematical modelling of glob-driven tear film breakup.Mathematical medicine and biology : a journal of the IMA · 2019Article
- Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery.Journal of ophthalmology · 2019Article
- Dynamics of Fluorescent Imaging for Rapid Tear Thinning.Bulletin of mathematical biology · 2019Article
- Mechanisms, imaging and structure of tear film breakup.The ocular surface · 2018Review
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- Evaporation and Hydrocarbon Chain Conformation of Surface Lipid Films.The ocular surface · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fluorescein tear film break-up test is a common tear film stability test for dry eye diagnosis. This test requires applying fluorescein sodium drops to a tear film to observe the tear film break-up. However, this test is limited by using the fluorescein sodium drops, which can induce reflex tearing and reduce the reliability of the diagnosis results. This paper proposes that tear film evaporation accelerates on the fluorescein tear film break-up area (FTBA), resulting in a lower temperature area (LTA) on the tear film. A dual modality system was established to capture the thermal and fluorescent image of fluorescein-stain tear films for 48 participants. Observations showed that the LTA and FTBA were highly correlated in their location (r = 0.82) and size (r = 0.91). This is first study to show that the FTBA and LTA are essentially the same region. This study demonstrated the feasibility of using the noncontact thermograph method to evaluate tear film stability without using a fluorescein sodium drop.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.