Evidence map›Paper›PMID 25136441›Full record

ReviewClinical and translational allergy2014

Operational definitions of asthma in recent epidemiological studies are inconsistent.

Ana Sá-Sousa, Tiago Jacinto, Luís Filipe Azevedo, Mário Morais-Almeida, Carlos Robalo-Cordeiro, António Bugalho-Almeida, Jean Bousquet, João Almeida Fonseca

Abstract readReview
In one paragraph

Review in Clinical and translational allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Asthma and pregnancy.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana Sá-SousaCenter for research in health technologies and information systems.- CINTESIS, Universidade do Porto, Porto, Portugal.
Tiago JacintoCenter for research in health technologies and information systems.- CINTESIS, Universidade do Porto, Porto, Portugal ; Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal.
Luís Filipe AzevedoCenter for research in health technologies and information systems.- CINTESIS, Universidade do Porto, Porto, Portugal ; Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
Mário Morais-AlmeidaAllergy and Clinical Immunology Department, Hospital CUF-Descobertas, Lisboa, Portugal.
Carlos Robalo-CordeiroAllergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
António Bugalho-AlmeidaClínica Universitária de Pneumologia-Faculdade de Medicina de Lisboa, Lisboa, Portugal.
Jean BousquetHôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France ; Centre de recherche en Epidémiologie et Santé des Populations, CESP Inserm U1018, Villejuif, France.
João Almeida FonsecaCenter for research in health technologies and information systems.- CINTESIS, Universidade do Porto, Porto, Portugal ; Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal ; Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Porto, Portugal ; Faculdade de Medicina da Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe best combination of questions to define asthma in epidemiological asthma studies is not known. We summarized the operational definitions of asthma used in prevalence studies and empirically assess how asthma prevalence estimates vary depending on the definition used.

methodsWe searched the Thomson Reuters ISI Web of knowledge and included (1) cross-sectional studies (2) on asthma prevalence (3) conducted in the general population and (4) containing an explicit definition of asthma. The search was limited to the 100 most-cited papers or published since January 2010. For each paper, we recorded the asthma definition used and other variables. Then we applied the definitions to the data of the Portuguese National Asthma survey (INAsma) and of the 2005-2006 National Health and Nutrition Examination Survey (NHANES) computing asthma prevalence estimates for the different definitions.

resultsOf 1738 papers retrieved, 117 were included for analysis. Lifetime asthma, diagnosed asthma and current asthma were defined in 8, 12 and 29 different ways, respectively. By applying definitions of current asthma on INAsma and NHANES data, the prevalence ranged between 5.3%-24.4% and 1.1%-17.2%, respectively.

conclusionsThere is considerable heterogeneity in the definitions of asthma used in epidemiological studies leading to highly variable estimates of asthma prevalence. Studies to inform a standardized operational definition are needed. Meanwhile, we propose a set of questions to be reported when defining asthma in epidemiological studies.

Indexed as

AsthmaDefinitionEpidemiologyPrevalenceReview

Identifiers

PMID25136441
PMCPMC4136946

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.