ReviewJournal of clinical and experimental dentistry2014
The role of topical simvastatin on bone regeneration: A systematic review.
Review in Journal of clinical and experimental dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- The evaluation of cytotoxicity and cytokine IL-6 production of root canal sealers with and without the incorporation of simvastatin: an invitro study.BMC oral health · 2022Article
- Medication-Related Osteonecrosis of the Jaw (MRONJ) due to Simvastatin: An Unusual Case Report.World journal of plastic surgery · 2021Article
- Statins, bone biology and revision arthroplasty: review of clinical and experimental evidence.Therapeutic advances in musculoskeletal disease · 2020Review
- 20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling.Journal of materials science. Materials in medicine · 2019Article
- 3D printed poly(ε-caprolactone) scaffolds function with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres to repair load-bearing segmental bone defects.Experimental and therapeutic medicine · 2019Article
- The Effect of Strontium Ranelate Gel on Bone Formation in Calvarial Critical Size Defects.Open access Macedonian journal of medical sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this systematic review was to summarize the results concerning the use of simvastatin for promoting bone regeneration and to discuss the level of scientific evidence supporting such findings. MATERIAL AND
methodsA Pubmed search using "Simvastatin"[Mesh] AND "Bone Regeneration"[Mesh] as Boolean operators was constrained to the last 10 years and only included papers written in English.
resultsOf the 41 relevant papers reviewed, most of them (76.2%) have been published in the last 5 years, and most of them address animal studies (66.6%) performed on rats or rabbits in extraoral regions. Only 4 randomized controlled trials (RCTs) assessed the role of topical simvastatin in periodontal patients.
conclusionsA large part of the evidence concerning the role of topical simvastatin on bone regeneration comes from animal studies (mainly rats) focusing on extraoral bone defects. Only the use of subgingival simvastatin after root scaling has been properly supported by RCT. Key words:Simvastatin, bone regeneration, topical administration, osteogenesis, osteoinduction.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.