ReviewSystems and synthetic biology2014
Swinging a sword: how microtubules search for their targets.
Review in Systems and synthetic biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation.Nature communications · 2026Article
- Tau condensation on DNA mediates microtubule attachment suggesting a mitotic role for centromere-localized tau.Nature communications · 2026Article
- Branching, crosslinking, and decentralization of microtubules accelerates intracellular assembly.Biophysical journal · 2025Article
- Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells.Current biology : CB · 2022Article
- Optimizing microtubule arrangements for rapid cargo capture.Biophysical journal · 2021Article
- Seasonal Effect on Developmental Competence, Oxidative Status and Tubulin Assessment of Prepubertal Ovine Oocyte.Animals : an open access journal from MDPI · 2021Article
- Dynamic Microtubule Arrays in Leukocytes and Their Role in Cell Migration and Immune Synapse Formation.Frontiers in cell and developmental biology · 2021Review
- Laying Tracks for Poison Delivery to "Kiss of Death": Search for Immune Synapse by Microtubules.Biophysical journal · 2019Article
- Search and Capture Efficiency of Dynamic Microtubules for Centrosome Relocation during IS Formation.Biophysical journal · 2019Article
- Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly.BMC biology · 2019Article
- Microtubules assemble near most kinetochores during early prometaphase in human cells.The Journal of cell biology · 2018Article
- Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles.European biophysics journal : EBJ · 2018Review
- Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I.Scientific reports · 2016Article
- Astral microtubule pivoting promotes their search for cortical anchor sites during mitosis in budding yeast.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell interior is in constant movement, which is to a large extent determined by microtubules, thin and long filaments that permeate the cytoplasm. To move large objects, microtubules need to connect them to the site of their destination. For example, during cell division, microtubules connect chromosomes with the spindle poles via kinetochores, protein complexes on the chromosomes. A general question is how microtubules, while being bound to one structure, find the target that needs to be connected to this structure. Here we review the mechanisms of how microtubules search for kinetochores, with emphasis on the recently discovered microtubule feature to explore space by pivoting around the spindle pole. In addition to accelerating the search for kinetochores, pivoting helps the microtubules to search for cortical anchors, as well as to self-organize into parallel arrays and asters to target specific regions of the cell. Thus, microtubule pivoting constitutes a mechanism by which they locate targets in different cellular contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.