Evidence map›Paper›PMID 25136370›Full record

ArticleStem cells international2014

Efficacy of topical mesenchymal stem cell therapy in the treatment of experimental dry eye syndrome model.

Emrullah Beyazyıldız, Ferda Alpaslan Pınarlı, Ozlem Beyazyıldız, Emine Rümeysa Hekimoğlu, Uğur Acar, Muhammed Necati Demir, Aynur Albayrak, Figen Kaymaz, Güngör Sobacı, Tuncay Delibaşı

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  9. Biomedical Application of MSCs in Corneal Regeneration and Repair.International journal of molecular sciences · 2025
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  13. Regenerative mechanisms of stem cells and their clinical applications for degenerative eye diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Emrullah BeyazyıldızDepartment of Ophthalmology, Samsun Research and Training Hospital, Kıranköy Mevkii, 55100 Samsun, Turkey.
Ferda Alpaslan PınarlıCenter of Cell Research and Genetic Diagnosis, Dışkapı Yıldırım Beyazıt Research Hospital, Etlik, 06010 Ankara, Turkey.
Ozlem BeyazyıldızDepartment of Ophthalmology, Samsun Research and Training Hospital, Kıranköy Mevkii, 55100 Samsun, Turkey.
Emine Rümeysa HekimoğluDepartment of Histology and Embryology, Kastamonu Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Uğur AcarDepartment of Ophthalmology, Kastamonu Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Muhammed Necati DemirDepartment of Ophthalmology, Faculty of Medicine, Yıldırım Beyazıt University, Bilkent, 06800 Ankara, Turkey.
Aynur AlbayrakDepartment of Pathology, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Dışkapı, 06110 Ankara, Turkey.
Figen KaymazDepartment of Histology and Embryology, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Güngör SobacıDepartment of Ophthalmology, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Tuncay DelibaşıDepartment of Endocrinology, Kastamonu Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Hacettepe University · TRDışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi · TRSamsun University · TRAnkara Yıldırım Beyazıt University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridine labeled MSCs (n = 9) or phosphate buffer solution (n = 7) were topically applied once daily for one week. Schirmer test, break-up time score, ocular surface evaluation tests, and corneal inflammatory index scoring tests were applied to all rats at baseline and after treatment. All rats were sacrificed after one week for histological and electron microscopic analysis. Results. Mean aqueous tear volume and tear film stability were significantly increased in rats treated with MSCs (P < 0.05). Infiltration of bromodeoxyuridine labeled MSCs into the meibomian glands and conjunctival epithelium was observed in MSCs treated rats. Increased number of secretory granules and number of goblet cells were observed in MSCs treated rats. Conclusion. Topical application of MSCs could be a safe and effective method for the treatment of DES and could potentially be used for further clinical research studies.

Identifiers

PMID25136370
PMCPMC4127226
OpenAlexW2153868165

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.