Evidence map›Paper›PMID 25136320›Full record

ReviewFrontiers in psychiatry2014

Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

Sylvie Tordjman, Eszter Somogyi, Nathalie Coulon, Solenn Kermarrec, David Cohen, Guillaume Bronsard, Olivier Bonnot, Catherine Weismann-Arcache, Michel Botbol, Bertrand Lauth and 6 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 5 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 5 syntheses or guidelines pooled it, 272 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
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  13. Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026
    Article
  14. Article
  15. Review
  16. The Neuroimmunology of Autism.Molecular neurobiology · 2025
    Review
  17. Article
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  20. Review

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 2 countries.

Sylvie TordjmanLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France ; Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Rennes 1, Centre Hospitalier Guillaume Régnier , Rennes , France.
Eszter SomogyiLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
Nathalie CoulonLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
Solenn KermarrecLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France ; Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Rennes 1, Centre Hospitalier Guillaume Régnier , Rennes , France.
David CohenDepartment of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, University Pierre and Marie Curie , Paris , France.
Guillaume BronsardLaboratoire de Santé Publique (EA3279), School of Medicine of La Timone , Marseille , France.
Olivier BonnotLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
Catherine Weismann-ArcacheLaboratoire Psychologie et Neurosciences de la Cognition et de l'Affectivité, Université de Rouen , Mont Saint Aignan , France.
Michel BotbolLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France ; Service Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Bretagne Occidentale, CHU de Brest , Brest , France.
Bertrand LauthDepartment of Child and Adolescent Psychiatry, Landspitali University Hospital, University of Iceland , Reykjavik , Iceland.
Vincent GinchatDepartment of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, University Pierre and Marie Curie , Paris , France.
Pierre RoubertouxLaboratoire de Génétique Médicale, Génomique Fonctionnelle, INSERM U 910, Université d'Aix-Marseille 2 , Marseille , France.
Marianne BarburothLaboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
Viviane KovessDepartment of Epidemiology and Biostatistics, EHESP School for Public Health, EA 4057 University Paris Descartes , Paris , France.
Marie-Maude GeoffrayService Universitaire de Psychiatrie de l'Enfant et de l'Adolescent Hospitalier Le Vinatier , Bron , France.
Jean XavierDepartment of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, University Pierre and Marie Curie , Paris , France.
Délégation Paris 5 · FRCentre National de la Recherche Scientifique · FRSorbonne Université · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Le Vinatier · FRÉcole des Hautes Études en Santé Publique · FRGénétique Médicale & Génomique Fonctionelle · FRNational University Hospital of Iceland · ISSanté Publique France · FRUniversité de Bretagne Occidentale · FRUniversité de Rouen Normandie · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with an increased risk for autism. Furthermore, several studies suggest a role of environmental factors in autism spectrum disorders (ASD). First, arguments for a genetic contribution to autism, based on updated family and twin studies, are examined. Second, a review of possible prenatal, perinatal, and postnatal environmental risk factors for ASD are presented. Then, the hypotheses are discussed concerning the underlying mechanisms related to a role of environmental factors in the development of ASD in association with genetic factors. In particular, epigenetics as a candidate biological mechanism for gene × environment interactions is considered and the possible role of epigenetic mechanisms reported in genetic disorders associated with ASD is discussed. Furthermore, the example of in utero exposure to valproate provides a good illustration of epigenetic mechanisms involved in ASD and innovative therapeutic strategies. Epigenetic remodeling by environmental factors opens new perspectives for a better understanding, prevention, and early therapeutic intervention of ASD.

Indexed as

autistic spectrum disordersenvironmentepigeneticsgene × environment interactionsmultidisciplinarymultifactorial

Identifiers

PMID25136320
PMCPMC4120683
OpenAlexW2133200116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.