ReviewFrontiers in physiology2014
Congenital heart malformations induced by hemodynamic altering surgical interventions.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 85 citations in OpenAlex.
- Antiemetic Combination Use During the First Trimester and Adverse Circulatory Outcomes in Newborn Infants: A Data-Mining Analysis.Drug safety · 2026Article
- Mitochondrial dysfunction underlies cardiac contractility and growth defects in a zebrafish model ofbioRxiv : the preprint server for biology · 2026Article
- A Parametric Finite Element Analysis of Chick Embryo Aortic Valve Leaflet Biomechanics.Bioengineering (Basel, Switzerland) · 2026Article
- Developmental and Evolutionary Heart Adaptations Through Structure-Function Relationships.Journal of cardiovascular development and disease · 2025Review
- An anatomically informed computational fluid dynamics modeling approach for quantifying hemodynamics in the developing heart.PloS one · 2025Article
- The Ongoing Relationship Between Offspring Congenital Heart Disease and Preeclampsia Across Pregnancies.JACC. Advances · 2024Article
- Hemodynamics During Development and Postnatal Life.Advances in experimental medicine and biology · 2024Review
- Molecular Pathways and Animal Models of Tetralogy of Fallot and Double Outlet Right Ventricle.Advances in experimental medicine and biology · 2024Review
- Standardisation and future of preclinical echocardiography.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- OCT Meets micro-CT: A Subject-Specific Correlative Multimodal Imaging Workflow for Early Chick Heart Development Modeling.Journal of cardiovascular development and disease · 2022Article
- Effect of Blood Flow on Cardiac Morphogenesis and Formation of Congenital Heart Defects.Journal of cardiovascular development and disease · 2022Review
- Flow-Mediated Factors in the Pathogenesis of Hypoplastic Left Heart Syndrome.Journal of cardiovascular development and disease · 2022Review
- Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish.Journal of cardiovascular development and disease · 2022Article
- Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo.Frontiers in physiology · 2022Article
- Introduction to Hemodynamic Forces Analysis: Moving Into the New Frontier of Cardiac Deformation Analysis.Journal of the American Heart Association · 2021Article
- Haemodynamic dependence of mechano-genetic evolution of the cardiovascular system in Japanese medaka.Journal of the Royal Society, Interface · 2021Article
- Fetal Blood Flow and Genetic Mutations in Conotruncal Congenital Heart Disease.Journal of cardiovascular development and disease · 2021Review
- Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve.Development (Cambridge, England) · 2021Article
- Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.Journal of cardiovascular development and disease · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic heart formation results from a dynamic interplay between genetic and environmental factors. Blood flow during early embryonic stages plays a critical role in heart development, as interactions between flow and cardiac tissues generate biomechanical forces that modulate cardiac growth and remodeling. Normal hemodynamic conditions are essential for proper cardiac development, while altered blood flow induced by surgical manipulations in animal models result in heart defects similar to those seen in humans with congenital heart disease. This review compares the altered hemodynamics, changes in tissue properties, and cardiac defects reported after common surgical interventions that alter hemodynamics in the early chick embryo, and shows that interventions produce a wide spectrum of cardiac defects. Vitelline vein ligation and left atrial ligation decrease blood pressure and flow; and outflow tract banding increases blood pressure and flow velocities. These three surgical interventions result in many of the same cardiac defects, which indicate that the altered hemodynamics interfere with common looping, septation and valve formation processes that occur after intervention and that shape the four-chambered heart. While many similar defects develop after the interventions, the varying degrees of hemodynamic load alteration among the three interventions also result in varying incidence and severity of cardiac defects, indicating that the hemodynamic modulation of cardiac developmental processes is strongly dependent on hemodynamic load.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.