Evidence map›Paper›PMID 25136146›Full record

ArticleMediators of inflammation2014

IL-17 genetic and immunophenotypic evaluation in chronic graft-versus-host disease.

Renata Gonçalves Resende, Jeane de Fátima Correia-Silva, Tarcília Aparecida Silva, Ulisses Eliezer Salomão, Luciano Marques-Silva, Érica Leandro Marciano Vieira, Walderez Ornelas Dutra, Ricardo Santiago Gomez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Correlation between acute myeloid leukemia and IL-17A, IL-17F, and IL-23R gene polymorphism.International journal of clinical and experimental pathology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renata Gonçalves ResendeServiço de Estomatologia, Hospital Municipal Odilon Behrens, Rua Formiga 50, 31110-430 Belo Horizonte, MG, Brazil.
Jeane de Fátima Correia-SilvaCentro Universitário Newton Paiva, Faculdade de Odontologia, Avenida Presidente Carlos Luz 220, 31230-010 Belo Horizonte, MG, Brazil.
Tarcília Aparecida SilvaDepartamento de Clínica, Patologia e Cirurgia Odontológicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Ulisses Eliezer SalomãoDepartamento de Odontologia Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Luciano Marques-SilvaCiodonto-Universidade FACSETE, Rua Itália Pontelo 50, 35700-170 Sete Lagoas, MG, Brazil.
Érica Leandro Marciano VieiraLaboratório Interdisciplinar de Pesquisa Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Alfredo Balena 190, 30130-10 Belo Horizonte, MG, Brazil.
Walderez Ornelas DutraDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Ricardo Santiago GomezDepartamento de Clínica, Patologia e Cirurgia Odontológicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although interleukin-17 (IL-17) is a recently discovered cytokine associated with several autoimmune diseases, its role in the pathogenesis of chronic graft-versus-host disease (cGVHD) was not established yet. The objective of this study was to investigate the association of IL17A and IL17F genes polymorphisms and IL-17A and IL-17F levels with cGVHD. IL-17A expression was also investigated in CD4(+) T cells of patients with systemic cGVHD. For Part I of the study, fifty-eight allo-HSCT recipients and donors were prospectively studied. Blood samples were obtained to determine IL17A and IL17F genes polymorphisms. Cytokines levels in blood and saliva were assessed by ELISA at days +35 and +100 after HSCT. In Part II, for the immunophenotypic evaluation, eight patients with systemic cGVHD were selected and the expression of IL-17A was evaluated. We found association between recipient AA genotype with systemic cGVHD. No association was observed between IL-17A levels and cGVHD. Lower IL-17A levels in the blood were associated with AA genotype. In flow cytometry analysis, decreased expression of IL-17A was observed in patients with cGVHD after stimulation. In conclusion, IL-17A may have an important role in the development of systemic cGVHD.

Indexed as

AdolescentAdultChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFlow CytometryGenotypeGraft vs Host DiseaseHumansInterleukin-17MaleMiddle AgedPolymorphism, GeneticYoung AdultInterleukin-17

Identifiers

PMID25136146
PMCPMC4129170

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.