ArticleProceedings of the National Academy of Sciences of the United States of America2014
Direct measurement of the dielectric polarization properties of DNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Beyond the 2D Plane: Interfacing Microwave Resonators with Bioreceptor-Functionalized Hydrogel Micropillars for Label-Free Enhanced Sensitivity Biosensing.ACS applied materials & interfaces · 2026Article
- Study of dielectric modulated dual source triple gate TFET for biosensing applications.Discover nano · 2025Article
- Targeting multidrug-resistant bacteria with genetic-information-free protein-only phages.bioRxiv : the preprint server for biology · 2025Article
- Development of 2D Microfluidics Surface with Low-Frequency Electric Fields for Cell Separation Applications.Sensors (Basel, Switzerland) · 2025Article
- A dual-fluorescence approach for turn-on ammonia and turn-off explosive picric acid detectionRSC advances · 2025Article
- DNA based nanoscale optoelectronic devices enabled by THz driven piezo vibrotronic effect.Scientific reports · 2025Article
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- Counterintuitive DNA destabilization by monovalent salt at high concentrations due to overcharging.Nature communications · 2025Article
- modXNA: A Modular Approach to Parametrization of Modified Nucleic Acids for Use with Amber Force Fields.Journal of chemical theory and computation · 2024Article
- Understanding Electrophoresis and Electroosmosis in Nanopore Sensing with the Help of the Nanopore Electro-Osmotic Trap.ACS nano · 2024Article
- Directed-evolution mutations enhance DNA-binding affinity and protein stability of the adenine base editor ABE8e.Cellular and molecular life sciences : CMLS · 2024Article
- The origin of different bending stiffness between double-stranded RNA and DNA revealed by magnetic tweezers and simulations.Nucleic acids research · 2024Article
- Probing the role of the protonation state of a minor groove-linker histidine in Exd-Hox-DNA binding.Biophysical journal · 2024Article
- Rationalizing the environment-dependent photophysical behavior of a DNA luminescent probe by classical and non-adiabatic molecular dynamics simulations.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection.Sensors (Basel, Switzerland) · 2023Article
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- A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics.Computational and structural biotechnology journal · 2023Article
- Combating Coronavirus Using Resonant Electromagnetic Irradiation.IEEE journal of electromagnetics, RF and microwaves in medicine and biology · 2022Article
- Molecular Insights into the Binding of Linear Polyethylenimines and Single-Stranded DNA Using Raman Spectroscopy: A Quantitative Approach.The journal of physical chemistry. B · 2022Article
- Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfORSC advances · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The electric polarizability of DNA, represented by the dielectric constant, is a key intrinsic property that modulates DNA interaction with effector proteins. Surprisingly, it has so far remained unknown owing to the lack of experimental tools able to access it. Here, we experimentally resolved it by detecting the ultraweak polarization forces of DNA inside single T7 bacteriophages particles using electrostatic force microscopy. In contrast to the common assumption of low-polarizable behavior like proteins (εr ∼ 2-4), we found that the DNA dielectric constant is ∼ 8, considerably higher than the value of ∼ 3 found for capsid proteins. State-of-the-art molecular dynamic simulations confirm the experimental findings, which result in sensibly decreased DNA interaction free energy than normally predicted by Poisson-Boltzmann methods. Our findings reveal a property at the basis of DNA structure and functions that is needed for realistic theoretical descriptions, and illustrate the synergetic power of scanning probe microscopy and theoretical computation techniques.
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