Evidence map›Paper›PMID 25136008›Full record

ArticleAntimicrobial agents and chemotherapy2014

Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center.

Jeffrey B Locke, Douglas E Zuill, Caitlyn R Scharn, Jennifer Deane, Daniel F Sahm, Richard V Goering, Stephen G Jenkins, Karen J Shaw

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Communications medicine · 2022
    Article
  2. Article
  3. Review
  4. In vitro activity of tedizolid against Staphylococcus aureus and Streptococcus pneumoniae collected in 2013 and 2014 from sites in Latin American countries, Australia, New Zealand, and China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Tedizolid phosphate.Hospital pharmacy · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jeffrey B LockeTrius Therapeutics, Inc., San Diego, California, USA jlocke@cidara.com.
Douglas E ZuillTrius Therapeutics, Inc., San Diego, California, USA.
Caitlyn R ScharnDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Jennifer DeaneEurofins Global Central Laboratory, Chantilly, Virginia, USA.
Daniel F SahmEurofins Global Central Laboratory, Chantilly, Virginia, USA.
Richard V GoeringDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Stephen G JenkinsNew York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, USA.
Karen J ShawTrius Therapeutics, Inc., San Diego, California, USA.
Arcturus Therapeutics (United States) · USCreighton University · USEurofins (United States) · USNew York Hospital Queens · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.

Indexed as

AcetamidesAnti-Bacterial AgentsBacterial ProteinsClindamycinDiterpenesDrug Resistance, Multiple, BacterialGene Transfer TechniquesHumansLinezolidMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular Sequence DataNew YorkOrganophosphatesOxazolesOxazolidinonesAcetamidesAnti-Bacterial AgentsBacterial ProteinsCFR protein, Staphylococcus aureusClindamycinDiterpenesflorfenicolLinezolidOrganophosphatesOxazolesOxazolidinonestedizolid phosphateThiamphenicoltiamulin

Identifiers

PMID25136008
PMCPMC4249436
OpenAlexW1971787097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.