ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03574662 (A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Prevalence of sarcopenia and its association with clinical outcomes in heart failure: An updated meta-analysis and systematic review.Clinical cardiology · 2023Pooled it
- Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Pooled it
- A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study.Calcified tissue international · 2016Trial
- Acute Sarcopenia: Mechanisms and Management.Nutrients · 2024Review
- Impact of Frailty on Inpatient Mortality and Resource Utilization for Primary Pulmonary Hypertension.Avicenna journal of medicine · 2024Article
- The Association of Neighborhood Characteristics and Frailty in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Sarcopenia in Menopausal Women: Current Perspectives.International journal of women's health · 2022Review
- Assessment of aerobic exercise capacity in obesity, which expression of oxygen uptake is the best?Sports medicine and health science · 2021Review
- Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era.International journal of endocrinology · 2021Review
- Barriers to eating are associated with poor physical function in older women.Preventive medicine · 2020Article
- Tai Chi and whole-body vibrating therapy in sarcopenic men in advanced old age: a clinical randomized controlled trial.European journal of ageing · 2019Article
- Do Nationally Representative Cutpoints for Clinical Muscle Weakness Predict Mortality? Results From 9 Years of Follow-up in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Frailty phenotypes and mortality after lung transplantation: A prospective cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults.Aging and disease · 2018Review
- Physical Therapy Considerations for Chronic Kidney Disease and Secondary Sarcopenia.Journal of functional morphology and kinesiology · 2018Article
- Frailty assessment in older adults with chronic obstructive respiratory diseases.Clinical interventions in aging · 2018Review
- Functional Limitations Among Responders to the World Trade Center Attacks 14 Years After the Disaster: Implications of Chronic Posttraumatic Stress Disorder.Journal of traumatic stress · 2017Article
- Combining Activity-Related Behaviors and Attributes Improves Prediction of Health Status in NHANES.Journal of physical activity & health · 2017Article
- Sarcopenia and the New ICD-10-CM Code: Screening, Staging, and Diagnosis Considerations.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2017Article
- Reliability, Validity, and Minimal Detectable Change of Four-Step Stair Climb Power Test in Community-Dwelling Older Adults.Physical therapy · 2017Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundThe Foundation for the National Institutes of Health Sarcopenia Project developed data-driven cut-points for clinically meaningful weakness and low lean body mass. This analysis describes strength and function response to interventions based on these classifications.
methodsIn data from four intervention studies, 378 postmenopausal women with baseline and 6-month data were evaluated for change in grip strength, appendicular lean mass corrected for body mass index, leg strength and power, and short physical performance battery (SPPB). Clinical interventions included hormones, exercise, and nutritional supplementation. Differences in outcomes were evaluated between (i) those with and without weakness and (ii) those with weakness and low lean mass or with one but not the other. We stratified analyses by slowness (walking speed ≤ 0.8 m/s) and by treatment assignment.
resultsThe women (72±7 years; body mass index of 26±5kg/m(2)) were weak (33%), had low lean mass (14%), or both (6%). Those with weakness increased grip strength, lost less leg power, and gained SPPB score (p < .05) compared with nonweak participants. Stratified analyses were similar for grip strength and SPPB. With lean mass in the analysis, individuals with weakness had larger gains in grip strength and SPPB scores regardless of low lean mass (p < .01).
conclusionsOlder women with clinically meaningful muscle weakness increased grip strength and SPPB, regardless of the presence of low lean mass following treatment with interventions for frailty. Thus, results suggest that muscle weakness, as defined by the Foundation for the National Institutes of Health Sarcopenia Project, appears to be a treatable symptom.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.