ArticleOphthalmology and therapy2013
Necrotizing scleritis and peripheral ulcerative keratitis associated with Wegener's granulomatosis.
Article in Ophthalmology and therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Peripheral Ulcerative Keratitis: Pathogenesis, Diagnosis, and Multimodal Management.Journal of clinical medicine · 2026Review
- Necrotizing Scleritis in Granulomatosis With Polyangiitis: A Clinical Challenge for an Ophthalmologists.Case reports in ophthalmological medicine · 2026Article
- The primary systemic vasculitis associated optic neuritis: a retrospective analysis in a single center over 10 years.International ophthalmology · 2024Article
- Ocular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care center.International ophthalmology · 2024Article
- ANCA-associated vasculitis presenting with progressive binocular manifestations: a case report and literature review.Frontiers in medicine · 2024Article
- Updates of ocular involvement in granulomatosis with polyangiitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- Clinical profile and management of granulomatosis with polyangiitis-associated scleritis from a tertiary care hospital in South India.Indian journal of ophthalmology · 2023Article
- A Case of an Elderly Woman Who Developed Corneal Perforation in the Clinical Course of Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.Case reports in rheumatology · 2023Article
- Scleritis: Differentiating infectious from non-infectious entities.Indian journal of ophthalmology · 2020Review
- A case of lung mass with no perception of light: Extreme ocular presentation of granulomatosis polyangiitis.Indian journal of ophthalmology · 2019Article
- Peripheral ulcerative keratitis and otitis media as initial symptoms of Wegener's granulomatosis: a case report.International journal of ophthalmology · 2019Article
- Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region.Indian journal of ophthalmology · 2018Article
- Clinical characteristics of inflammatory ocular disease in anti-neutrophil cytoplasmic antibody associated vasculitis: a retrospective cohort study.Rheumatology (Oxford, England) · 2017Article
- A case report of the orbit, ocular association and the lung in granulomatosis with polyangiitis: A diagnostic challenge.Experimental and therapeutic medicine · 2017Article
- Peripheral Ulcerative Keratitis Associated with Autoimmune Disease: Pathogenesis and Treatment.Journal of ophthalmology · 2017Review
- GNE Myopathy and Cell Apoptosis: A Comparative Mutation Analysis.Molecular neurobiology · 2016Article
- Ocular Involvement in Systemic Autoimmune Diseases.Clinical reviews in allergy & immunology · 2015Review
- Etiology, clinical profile, and treatment outcome of peripheral ulcerative keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Deep Anterior Lamellar Keratoplasty and Peripheral Lamellar Keratoplasty for a Case of Severe Peripheral Ulcerative Keratitis.Case reports in ophthalmologyArticle
- Therapy of ocular complications in ANCA+ associated vasculitis.Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo evaluate the complications, efficacy of medical and surgical treatment, and outcome in patients with necrotizing scleritis and peripheral ulcerative keratitis associated with Wegener's granulomatosis.
methodsThe authors reviewed a series of seven patients with Wegener's granulomatosis treated in the Corneal Department of Zhongshan Ophthalmic Center and the Department of Ophthalmology of Kashgar First People's Hospital. A detailed chart review was performed to determine demographic characteristics, ocular presentation, biopsy and laboratory testing results, treatment, and final outcome.
resultsWegener's granulomatosis was indicated by ocular and/or systemic findings; biopsy and immunohistochemistry results supported the diagnosis. Patients with necrotizing scleritis and/or peripheral ulcerative keratitis received cytotoxic immunosuppressive therapy; this, in conjunction with surgical treatment, halted the relentlessly progressive inflammation and preserved the integrity of the globe in 78% of eyes. Best-Corrected Visual Acuity remained stable in four of nine eyes, was improved in two of nine eyes, and decreased in three of nine eyes (secondary to cataract and/or stromal scarring). Although one patient died, treatment with corticosteroids and cytotoxic agents dramatically improved outcomes in these patients.
conclusionNecrotizing scleritis and peripheral ulcerative keratitis often have a poor visual outcome, and may herald an underlying systemic vasculitis. Wegener's granulomatosis, with the associated necrotizing scleritis and peripheral ulcerative keratitis, should be managed with aggressive immunosuppression to avoid the associated morbidity and mortality. Thus, the ophthalmologist may play a significant role in its early diagnosis and treatment.
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Registered trials
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