ArticleTransfusion2014
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Article in Transfusion, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Red blood cell transfusion management for people undergoing cardiac surgery for congenital heart disease.The Cochrane database of systematic reviews · 2025Pooled it
- Red Cell Transfusion in General Medicine Patients at Teaching and Non-teaching Hospitals: A Retrospective Cohort Analysis.Journal of general internal medicine · 2026Article
- Specific Trends in Blood Utilization During the COVID-19 Pandemic: A Retrospective Analysis of a Hungarian Clinical Centre.Journal of clinical medicine · 2025Article
- Rising transfusion rates amidst stable blood supply: A Canadian perspective on emerging challenges for blood operators.Transfusion · 2025Article
- Review
- The association of perioperative blood transfusion with survival outcomes after major cancer surgery: a population-based cohort study in South Korea.Surgery today · 2024Article
- Patient blood management to minimize transfusions during the postpartum period.Obstetrics & gynecology science · 2023Article
- Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice.Frontiers in immunology · 2023Article
- Iatrogenic blood loss in critical care: A prospective observational study conducted at Universitas Academic Hospital in the Free State Province, South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2022Article
- The Impact of Preoperative Intravenous Iron Therapy on Perioperative Outcomes in Cardiac Surgery: A Systematic Review.Journal of hematology · 2020Review
- Red blood cell transfusions for emergency department patients with gastrointestinal bleeding within an integrated health system.The American journal of emergency medicine · 2020Article
- Patient blood management (PBM) in pregnancy and childbirth: literature review and expert opinion.Archives of gynecology and obstetrics · 2020Review
- Methodological considerations for linked blood donor-component-recipient analyses in transfusion medicine research.ISBT science series · 2020Article
- Preoperative Anemia Treatment With Intravenous Iron in Patients Undergoing Major Orthopedic Surgery: A Systematic Review.Geriatric orthopaedic surgery & rehabilitation · 2020Article
- Clinical decision support and improved blood use in patient blood management.Hematology. American Society of Hematology. Education Program · 2019Review
- Article
- Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study.Annals of internal medicine · 2019Article
- TACO and TRALI: biology, risk factors, and prevention strategies.Hematology. American Society of Hematology. Education Program · 2018Review
- Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundBlood conservation strategies have been shown to be effective in decreasing red blood cell (RBC) utilization in specific patient groups. However, few data exist describing the extent of RBC transfusion reduction or their impact on transfusion practice and mortality in a diverse inpatient population. STUDY DESIGN AND
methodsWe conducted a retrospective cohort study using comprehensive electronic medical record data from 21 medical facilities in Kaiser Permanente Northern California. We examined unadjusted and risk-adjusted RBC transfusion and 30-day mortality coincident with implementation of RBC conservation strategies.
resultsThe inpatient study cohort included 391,958 patients who experienced 685,753 hospitalizations. From 2009 to 2013, the incidence of RBC transfusion decreased from 14.0% to 10.8% of hospitalizations; this change coincided with a decline in pretransfusion hemoglobin (Hb) levels from 8.1 to 7.6 g/dL. Decreased RBC utilization affected broad groups of admission diagnoses and was most pronounced in patients with a nadir Hb level between 8 and 9 g/dL (n = 73,057; 50.8% to 19.3%). During the study period, the standard deviation of risk-adjusted RBC transfusion incidence across hospitals decreased by 44% (p < 0.001). Thirty-day mortality did not change significantly with declines in RBC utilization in patient groups previously studied in clinical trials nor in other subgroups.
conclusionsAfter the implementation of blood conservation strategies, RBC transfusion incidence and pretransfusion Hb levels decreased broadly across medical and surgical patients. Variation in RBC transfusion incidence across hospitals decreased from 2010 to 2013. Consistent with clinical trial data, more restrictive transfusion practice did not appear to impact 30-day mortality.
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