ArticleCurrent genetics2015
Purifying selection against gene conversions between the polyamine transport (TPO) genes of Saccharomyces species.
Article in Current genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- TPO1-based polyamines transport contributes to pathogenicity of sugarcane smut fungus.Mycology · 2026Article
- Genetic portrait of polyamine transporters in barley: insights in the regulation of leaf senescence.Frontiers in plant science · 2023Article
- Negative epistasis: a route to intraspecific reproductive isolation in yeast?Current genetics · 2016Review
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Authors and funding
2 authors.
Funding
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Abstract
Saccharomyces species have five TPO genes, TPO1 through TPO5, coding for proteins that are involved in up taking or excreting intracellular spermine, putrescine or spermidine. Here, we investigate the evolutionary fate and functional impacts of gene conversions between these genes. Our results show that gene conversions occurred only between the TPO2 and TPO3 genes of the six Saccharomyces species we studied. They also show that these gene conversions occurred independently in all six species. The facts that they only occur between closely related genes having similar function, and that they are limited to the transmembrane domain of these proteins, suggest that they have little functional impact. These gene conversions therefore likely represent neutral mutations which are not subject to purifying selection.
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