ReviewEnvironmental health and preventive medicine2014
Silica exposure and altered regulation of autoimmunity.
Review in Environmental health and preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Silicosis, Sarcoidosis, and Silicosarcoidosis Are Overlapping Diagnoses and Difficult to Differentiate.American journal of industrial medicine · 2026Article
- Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice.Particle and fibre toxicology · 2026Article
- Pneumoconiosis and Chronic Diseases: A Narrative Review.Iranian journal of public health · 2025Review
- A toxicological profile of silica nanoparticles.Toxicology research · 2022Review
- Rheumatological Diseases in Denim Sandblasters with Silicosis: What Should Pulmonologists Look for?Turkish thoracic journal · 2020Article
- The Effects of Asbestos Fibers on Human T Cells.International journal of molecular sciences · 2020Review
- Imaging flow cytometry methods for quantitative analysis of label-free crystalline silica particle interactions with immune cells.AIMS biophysics · 2020Article
- Role of Nephronectin in Pathophysiology of Silicosis.International journal of molecular sciences · 2019Review
- Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation.Pharmaceutics · 2019Review
- Silica Particles Mediate Phenotypic and Functional Alteration of Dendritic Cells and Induce Th2 Cell Polarization.Frontiers in immunology · 2019Article
- Silicosis, then microscopic polyangiitis-antineutrophil cytoplasmic antibodies-associated vasculitis may be work-related disease in patients with silicosis.Journal of general and family medicine · 2017Article
- Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.Environmental health and preventive medicine · 2017Review
- Clinical evaluation of CENP-B and Scl-70 autoantibodies in silicosis patients.Experimental and therapeutic medicine · 2017Article
- Accelerated cell cycle progression of human regulatory T cell-like cell line caused by continuous exposure to asbestos fibers.International journal of oncology · 2017Article
- Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment.Environmental health and preventive medicine · 2016Review
- Diagnosis of perinuclear anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis in silicotics: case report.Annals of occupational and environmental medicine · 2016Article
- Association between environmental exposures and granulomatosis with polyangiitis in Canterbury, New Zealand.Arthritis research & therapy · 2015Article
- Sjögren's Syndrome and Silicosis - a Case Report.Open access Macedonian journal of medical sciences · 2015Article
- Article
- Two Cases of Tsunami Dust Pneumonia: Organizing Pneumonia Caused by the Inhalation of Dried Tsunami Sludge after the 2011 Great East Japan Earthquake.Internal medicine (Tokyo, Japan)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silica particles and asbestos fibers, which are known as typical causatives of pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with autoimmune diseases, and asbestos-exposed patients suffer from malignant diseases such as pleural mesothelioma and lung cancer. We have been conducting experimental studies to investigate altered regulation of self-tolerance caused by silica exposure, including analyses using specimens such as plasma and immunocompetent cells obtained from silicosis patients, as a means of examining the supposition that silica exposure induces molecular and cellular biological alterations of immune cells. These approaches have resulted in the detection of several specific autoantibodies, alterations of CD95/Fas and its related molecules, and evidence of chronic activation of responder T cells and regulatory T cells following silica exposure. In this review, we present details of our investigations as an introduction to scientific approaches examining the immunological effects of environmental and occupational substances.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.