ArticleOphthalmology and therapy2013
Evaluation of retinal nerve fiber layer changes with oral isotretinoin treatment.
Article in Ophthalmology and therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 10 citations in OpenAlex.
- Highlighting Ophthalmic Adverse Effects Associated with Isotretinoin.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCentral nervous system toxicity is a well-known side effect of isotretinoin treatment. The aim of this study was to establish the effects of isotretinoin on retinal nerve fiber layer (RNFL) thickness. MATERIALS AND
methodsStudy subjects received oral isotretinoin treatment for nodulocystic acne. All patients underwent a detailed ophthalmologic examination including best-corrected visual acuity, slit-lamp examination, tonometry, color vision assessment, fundoscopy, and RNFL measurement. RNFL measurements by optical coherence tomography were done at onset, and were repeated at the 1st and 6th months of therapy.
resultsA total of 22 eyes of 11 patients (seven males and four females) were included in this study. The mean age of the patients was 20.18 ± 5.13 (14-26) years. Mean RNFL thickness was 90.72 ± 9.19 (78.2-112.0) μm before treatment, 90.40 ± 9.24 (79.5-112.4) μm after 1 month of treatment, and 90.52 ± 8.92 (78.4-114.8) μm after 6 months. No statistically significant change was detected between RNFL thickness values before and after treatment.
conclusionNo adverse effects of systemic isotretinoin treatment on RNFL thickness were observed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.