SynthesisThe Cochrane database of systematic reviews2014
Modest cooling therapies (35ºC to 37.5ºC) for traumatic brain injury.
Synthesis in The Cochrane database of systematic reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Interventions to reduce body temperature to 35 ⁰C to 37 ⁰C in adults and children with traumatic brain injury.The Cochrane database of systematic reviews · 2020Pooled it
- The Role of Hypothermia in Large Hemispheric Infarction: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Fever Control Management Is Preferable to Mild Therapeutic Hypothermia in Traumatic Brain Injury Patients with Abbreviated Injury Scale 3-4: A Multi-Center, Randomized Controlled Trial.Journal of neurotrauma · 2016Trial
- The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial.PloS one · 2015Trial
- Article
- Neurorehabilitation: applied neuroplasticity.Journal of neurology · 2017Review
- The far-reaching scope of neuroinflammation after traumatic brain injury.Nature reviews. Neurology · 2017Review
- Study protocol - A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: Why have promising animal studies not been replicated in pragmatic clinical trials?Evidence-based preclinical medicine · 2016Review
- Hypothermia for severe traumatic brain injury in adults: Recent lessons from randomized controlled trials.Surgical neurology international · 2016Article
- What's New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment.International journal of molecular sciences · 2015Review
- Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection.Intensive care medicine · 2015Article
- Body Temperature after EMS Transport: Association with Traumatic Brain Injury Outcomes.Prehospital emergency careObservational
Corrections and comments
- Updated by
- Update of
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAnimal models of traumatic brain injury suggest that induced normothermia (36.5 or 37 ºC), compared to induced hyperthermia (39 ºC), improves histopathological and neurobehavioural outcomes. Observational clinical studies of patients with TBI suggest an association between raised body temperature and unfavourable outcome, although this relationship is inconsistent.
objectivesTo assess the effects of modest cooling therapies (defined as any drug or physical therapy aimed at maintaining body temperature between 35 ºC and 37.5 ºC) when applied to patients in the first week after traumatic brain injury. SEARCH
methodsThe most recent search was run on 23(rd) September 2013. We searched the Cochrane Injuries Group's Specialised Register, The Cochrane Library (CENTRAL), MEDLINE (OvidSP), Embase (OvidSP), ISI WOS: SCI-EXPANDED (1970) & CPCI-S (1990), PubMed and trials registries together with reference checking. SELECTION CRITERIA: All completed randomised, controlled and placebo-controlled trials published or unpublished, where modest cooling therapies were applied in the first week after traumatic brain injury. DATA COLLECTION AND ANALYSIS: Two authors independently applied the selection criteria to relevant trials. MAIN
resultsWe were unable to find any randomised controlled trials of modest cooling therapies after traumatic brain injury. AUTHORS'
conclusionsIn order to further explore the preliminary findings provided by animal models and observational clinical studies that suggests there may be a beneficial effect of modest cooling for TBI, randomised trials designed to explore the effect of these interventions on patient-centred outcomes are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.