ArticleInternational journal of obesity (2005)2015
Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 57 citations in OpenAlex.
- Socioeconomic disadvantage and polygenic risk of overweight in early and mid-life: a longitudinal population cohort study spanning 12 years.The Lancet regional health. Western Pacific · 2024Article
- Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.Journal Of Economic Psychology · 2023Article
- Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.Advances in nutrition (Bethesda, Md.) · 2021Review
- Interaction of Neighborhood and Genetic Risk on Waist Circumference in African-American Adults: A Longitudinal Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Article
- Methylation and Expression ofNutrients · 2021Article
- The obesity epidemic - Nature via nurture: A narrative review of high-income countries.SAGE open medicine · 2020Review
- Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.Obesity (Silver Spring, Md.) · 2019Article
- Article
- Variation in the Heritability of Child Body Mass Index by Obesogenic Home Environment.JAMA pediatrics · 2018Article
- Food Consumption as a Modifier of the Association betweenNutrients · 2018Article
- Cohort Profile: The transition from childhood to adolescence in European children-how I.Family extends the IDEFICS cohort.International journal of epidemiology · 2017Article
- Gene-Diet Interaction and Precision Nutrition in Obesity.International journal of molecular sciences · 2017Review
- Article
- Behavioural Susceptibility Theory: Professor Jane Wardle and the Role of Appetite in Genetic Risk of Obesity.Current obesity reports · 2017Review
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
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Authors and funding
18 authors at 11 institutions in 9 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N = 4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort.
methodsA structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES.
resultsSignificant main effects are shown for physical activity and fitness (standardised [betacrc ](s) = -0.113), SES ([betacrc ](s) = -0.057) and the FTO homozygous AA risk genotype ([betacrc ](s) = -0.177). The explained variance of obesity is ~9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ(2) = 7.3, df = 2, P = 0.03).
conclusionChildren carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.
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