Evidence map›Paper›PMID 25134760›Full record

ArticleThe American journal of pathology2014

Evidence that meningeal mast cells can worsen stroke pathology in mice.

Ahmet Arac, Michele A Grimbaldeston, Andrew R B Nepomuceno, Oluwatobi Olayiwola, Marta P Pereira, Yasuhiro Nishiyama, Anna Tsykin, Gregory J Goodall, Ulrich Schlecht, Hannes Vogel and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Review
  4. Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Review
  7. Antidepressant-like Effects ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Absence of meningeal mast cells in theFrontiers in cellular neuroscience · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Investigating theOxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Ahmet AracDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California.
Michele A GrimbaldestonStanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California; Division of Human Immunology, Center for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia; School of Molecular & Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia. Electronic address: michele.grimbaldeston@unisa.edu.au.
Andrew R B NepomucenoDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California.
Oluwatobi OlayiwolaDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California.
Marta P PereiraDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California; Department of Molecular Biology and Center of Molecular Biology "Severo Ochoa", Universidad Autonoma de Madrid, Madrid, Spain.
Yasuhiro NishiyamaDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California.
Anna TsykinDivision of Human Immunology, Center for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia; School of Molecular & Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia.
Gregory J GoodallDivision of Human Immunology, Center for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia; School of Molecular & Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia.
Ulrich SchlechtDepartment of Biochemistry, School of Medicine, Stanford University, Stanford, California.
Hannes VogelStanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California; Department of Pathology, School of Medicine, Stanford University, Stanford, California.
Mindy TsaiStanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California; Department of Pathology, School of Medicine, Stanford University, Stanford, California.
Stephen J GalliStanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California; Department of Pathology, School of Medicine, Stanford University, Stanford, California; Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, California. Electronic address: sgalli@stanford.edu.
Tonya M BlissDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California. Electronic address: tbliss1@stanford.edu.
Gary K SteinbergDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California; Stanford Stroke Center, School of Medicine, Stanford University, Stanford, California; Stanford Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford University, Stanford, California. Electronic address: gsteinberg@stanford.edu.
Stanford University · USStanford Medicine · USCentre for Cancer Biology · AUSouth Australia Pathology · AU

Funding

Transgenic animal injury paradigmsP01NS037520 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 1999 to 2008
$10.8M
Role of Mast Cells in Inflammation and ImmunityR01CA072074 · NCI · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 1996 to 2010
$4.4M
Expression and Modulation of Mast Cell Function in AsthmaR01AI070813 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2006 to 2010
$2.5M
Regulation of Mast Cell Development and FunctionR01AI023990 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 1986 to 2010
$2.4M
REGULATION OF MAST CELL DEVELOPMENT &FUNCTIONR37AI023990 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN J · 1996 to 2005
$2.2M
Meningeal Mast Cells: Key effectors of stroke pathologyR21NS080062 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2013 to 2014
$431k
NCI NIH HHS CA072074NCI NIH HHS R01 CA072074NIAID NIH HHS AI023990NIAID NIH HHS AI070813NIAID NIH HHS R01 AI023990NIAID NIH HHS R01 AI070813NIAID NIH HHS R37 AI023990NINDS NIH HHS NS080062NINDS NIH HHS NS37520-08NINDS NIH HHS P01 NS037520NINDS NIH HHS R21 NS080062
6 · The paper itself

Abstract

Stroke is the leading cause of adult disability and the fourth most common cause of death in the United States. Inflammation is thought to play an important role in stroke pathology, but the factors that promote inflammation in this setting remain to be fully defined. An understudied but important factor is the role of meningeal-located immune cells in modulating brain pathology. Although different immune cells traffic through meningeal vessels en route to the brain, mature mast cells do not circulate but are resident in the meninges. With the use of genetic and cell transfer approaches in mice, we identified evidence that meningeal mast cells can importantly contribute to the key features of stroke pathology, including infiltration of granulocytes and activated macrophages, brain swelling, and infarct size. We also obtained evidence that two mast cell-derived products, interleukin-6 and, to a lesser extent, chemokine (C-C motif) ligand 7, can contribute to stroke pathology. These findings indicate a novel role for mast cells in the meninges, the membranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathology after stroke.

Indexed as

AnimalsBrainDisease Models, AnimalFlow CytometryGene Knock-In TechniquesMagnetic Resonance ImagingMaleMast CellsMeningesMiceMice, Inbred C57BLMice, KnockoutStroke

Identifiers

PMID25134760
PMCPMC4188278
OpenAlexW2157668990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.