ReviewNature reviews. Neurology2014
Mechanism-based treatment in complex regional pain syndromes.
Review in Nature reviews. Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- A Systematic Critical Appraisal of Clinical Practice Guidelines for Non-Pharmacological Conservative Management of Complex Regional Pain Syndrome (CRPS) Using the AGREE-II Instrument.Journal of evaluation in clinical practice · 2026Pooled it
- Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial.Regional anesthesia and pain medicine · 2024Trial
- Automatic quantification of thermographic images of complex regional pain syndrome using radiomics and deep learning.Pain reports · 2026Article
- Elevated Serum Soluble CD163 Indicates Macrophage Activation: A Potential Biomarker for Inflammation in Complex Regional Pain Syndrome?Pain practice : the official journal of World Institute of Pain · 2026Article
- How postmenopausal osteoporosis influences epidemiology and clinical features of CRPS-1.Journal of bone and mineral metabolism · 2026Article
- A Model of Body Perception Disturbances in Chronic Limb Pain: The Predictive Role of Kinesiophobia, Depersonalization and Symptom Severity.European journal of pain (London, England) · 2025Article
- [Cognitive behavioral therapy for complex regional pain syndrome].Schmerz (Berlin, Germany) · 2025Article
- Comprehensive Mechanisms and Non-Invasive Treatment for Complex Regional Pain Syndrome: A Narrative Review.Journal of pain research · 2025Review
- Repetitive Transcranial Magnetic Stimulation for the Treatment of Complex Regional Pain Syndrome: A Pilot Study.Journal of pain research · 2025Article
- Repetitive Transcranial Magnetic Stimulation with Sensorimotor Training for the Treatment of Complex Regional Pain Syndrome Type 2 of the Upper Limb Case Report.A&A practice · 2024Article
- A surgical approach to complex regional pain syndrome with neurogenic thoracic outlet syndrome in a reoperation patient.Pain management · 2024Article
- Peripheral BDNF Regulates Somatosensory-Sympathetic Coupling in Brachial Plexus Avulsion-Induced Neuropathic Pain.Neuroscience bulletin · 2023Article
- The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain.Pain reports · 2023Article
- Central sensitization in CRPS patients with widespread pain: a cross-sectional study.Pain medicine (Malden, Mass.) · 2023Article
- Person-centred management of upper limb complex regional pain syndrome: an integrative review of non-pharmacological treatment.Hand therapy · 2023Review
- Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.Journal of pain research · 2023Review
- Systemic, Intrathecal, and Intracerebroventricular Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512-2 Toxin in Persistent Pain Models.Molecular neurobiology · 2022Article
- From a Symptom-Based to a Mechanism-Based Pharmacotherapeutic Treatment in Complex Regional Pain Syndrome.Drugs · 2022Review
- Complex Regional Pain Syndrome in Athletes: Scoping Review.Medicina (Kaunas, Lithuania) · 2021Article
- Effect of intravenous low-dose S-ketamine on pain in patients with Complex Regional Pain Syndrome: A retrospective cohort study.Pain practice : the official journal of World Institute of Pain · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex regional pain syndromes (CRPS) are multifactorial disorders with complex aetiology and pathogenesis. Management of CRPS is challenging, partly because of a lack of clinical data regarding the efficacy of the various therapies, and partly because successful treatment of CRPS requires a multidisciplinary, patient-tailored approach. The pain in CRPS is often described as typical 'burning' neuropathic pain, and is accompanied by a variety of sensory, motor and autonomic signs and symptoms. Because research into therapies specifically in CRPS has been scarce, treatment for these syndromes has been largely based on therapeutic strategies adapted from neuropathic pain states; however, increased understanding of the pathogenesis of CRPS has provided the opportunity to develop mechanism-based treatments. The interactions between the multiple pathophysiological mechanisms that contribute to the development, progression and maintenance of CRPS remain poorly understood. This Review describes the challenges in linking the current theories and knowledge of pathophysiological mechanisms to the mode of actions of the different treatment approaches. We discuss the current treatment strategies for CRPS, including pharmacotherapy, sympathetic ganglion block interventions, psychological support, physiotherapy and occupational therapy, and establish the concept of mechanism-based treatment for CRPS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.