Evidence map›Paper›PMID 25134047›Full record

Trial reportPsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2015

Employment-based reinforcement of adherence to oral naltrexone in unemployed injection drug users: 12-month outcomes.

Kelly Dunn, Anthony DeFulio, Jeffrey J Everly, Wendy D Donlin, Will M Aklin, Paul A Nuzzo, Jeannie-Marie S Leoutsakos, Annie Umbricht, Michael Fingerhood, George E Bigelow and 1 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Contingency Management for Drug Use Disorders: Meta-Analysis and Application of Tolin's Criteria.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Abstinence-dependent dissociable central amygdala microcircuits control drug craving.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kelly DunnDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Anthony DeFulioDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Jeffrey J EverlyDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Wendy D DonlinDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Will M AklinDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Paul A NuzzoDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Jeannie-Marie S LeoutsakosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Annie UmbrichtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Michael FingerhoodDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
George E BigelowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Kenneth SilvermanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
Employment-Based Addiction PharmacotherapyR01DA019386 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SILVERMAN, KENNETH · 2005 to 2009
$3.1M
NIDA NIH HHS R01 DA019386NIDA NIH HHS R01DA019386NIDA NIH HHS T32 DA007209NIDA NIH HHS T32DA07209
6 · The paper itself

Abstract

Oral naltrexone could be a promising relapse-prevention pharmacotherapy for recently detoxified opioid-dependent patients; however, interventions are often needed to promote adherence with this treatment approach. We recently conducted a study to evaluate a 26-week employment-based reinforcement intervention of oral naltrexone in unemployed injection drug users (Dunn et al., 2013). Participants were randomly assigned into a contingency (n = 35) group required to ingest naltrexone under staff observation to gain entry into a therapeutic workplace or a prescription (n = 32) group given a take-home supply of oral naltrexone and access to the workplace without observed ingestion. Monthly urine samples were collected and analyzed for evidence for naltrexone adherence, opioid use, and cocaine use. As previously reported, contingency participants provided significantly more naltrexone-positive urine samples than prescription participants during the 26-week intervention period. The goal of this current study is to report the 12-month outcomes, which occurred 6 months after the intervention ended. Results at the 12-month visit showed no between-groups differences in naltrexone-positive, opioid-negative, or cocaine-negative urine samples and no participant self-reported using naltrexone at the follow-up visit. These results show that even after a period of successfully reinforced oral naltrexone adherence, longer-term naltrexone use is unlikely to be maintained after reinforcement contingencies are discontinued. (PsycINFO Database Record

Indexed as

EmploymentMedication AdherenceReinforcement, PsychologyAdultCocaine-Related DisordersDrug UsersFemaleFollow-Up StudiesHumansInjectionsMaleMiddle AgedNaltrexoneOpioid-Related DisordersSecondary PreventionTreatment OutcomeNaltrexone

Identifiers

PMID25134047
PMCPMC4339630
OpenAlexW2143468987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.