Trial reportMedicine and science in sports and exercise2014
Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat.
Trial report in Medicine and science in sports and exercise, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fatty infiltration in the thigh muscles in knee osteoarthritis: a systematic review and meta-analysis.Rheumatology international · 2019Pooled it
- Continuous care intervention with carbohydrate restriction improves physical function of the knees among patients with type 2 diabetes: a non-randomized study.BMC musculoskeletal disorders · 2022Trial
- Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial.Cells, tissues, organs · 2017Trial
- Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis.Osteoarthritis and cartilage · 2015Trial
- Association between central obesity and MRI-based biomarkers of knee osteoarthritis independent of BMI: A cross-sectional study from the Osteoarthritis Initiative database.Osteoarthritis and cartilage open · 2026Article
- [Disease burden trends of site-specific osteoarthritis in China from 1990 to 2023 and the attribution to high body mass index].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Article
- Aberrant Gait Biomechanics Linked to Cartilage Changes After ACL Reconstruction in Those With High Body Mass Index.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Differences in fatty infiltration in thigh muscles and physical function between people with and without knee osteoarthritis and similar body mass index: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Identification and functional analysis of hub genes in knee osteoarthritis via bioinformatics and experimental validation.Frontiers in bioinformatics · 2025Article
- Comparison of gait analysis before and after unilateral total knee arthroplasty for knee osteoarthritis.Journal of orthopaedic surgery and research · 2024Article
- Thigh muscle and fat volumes are associated with knee cartilage abnormalities and bone marrow edema-like lesions: data from the osteoarthritis initiative.Skeletal radiology · 2024Article
- Assessment of functional prognosis of anterior cruciate ligament reconstruction in athletes based on a body shape index.World journal of clinical cases · 2023Article
- High prevalence of patellofemoral osteoarthritis in China: a multi-center population-based osteoarthritis study.Clinical rheumatology · 2020Article
- Nonsurgical Management of Cartilage Defects of the Knee: Who, When, Why, and How?The journal of knee surgery · 2020Review
- Is local or central adiposity more strongly associated with incident knee osteoarthritis than the body mass index in men or women?Osteoarthritis and cartilage · 2018Article
- Mediating role of body mass index in knee osteoarthritis.Journal of Taibah University Medical Sciences · 2017Article
- Are unilateral and bilateral knee osteoarthritis patients unique subsets of knee osteoarthritis? A biomechanical perspective.Osteoarthritis and cartilage · 2016Article
- Longitudinal (4 year) change of thigh muscle and adipose tissue distribution in chronically painful vs painless knees--data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2015Article
- Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content--data from the Osteoarthritis Initiative.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeUsing three separate models that included total body mass, total lean and total fat mass, and abdominal and thigh fat as independent measures, we determined their association with knee joint loads in older overweight and obese adults with knee osteoarthritis (OA).
methodsFat depots were quantified using computed tomography, and total lean and fat mass were determined with dual energy x-ray absorptiometry in 176 adults (age, 66.3 yr; body mass index, 33.5 kg·m) with radiographic knee OA. Knee moments and joint bone-on-bone forces were calculated using gait analysis and musculoskeletal modeling.
resultsHigher total body mass was significantly associated (P ≤ 0.0001) with greater knee compressive and shear forces, compressive and shear impulses (P < 0.0001), patellofemoral forces (P < 0.006), and knee extensor moments (P = 0.003). Regression analysis with total lean and total fat mass as independent variables revealed significant positive associations of total fat mass with knee compressive (P = 0.0001), shear (P < 0.001), and patellofemoral forces (P = 0.01) and knee extension moment (P = 0.008). Gastrocnemius and quadriceps forces were positively associated with total fat mass. Total lean mass was associated with knee compressive force (P = 0.002). A regression model that included total thigh and total abdominal fat found that both were significantly associated with knee compressive and shear forces (P ≤ 0.04). Thigh fat was associated with knee abduction (P = 0.03) and knee extension moment (P = 0.02).
conclusionsThigh fat, consisting predominately of subcutaneous fat, had similar significant associations with knee joint forces as abdominal fat despite its much smaller volume and could be an important therapeutic target for people with knee OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.