Trial reportBone marrow transplantation2014
Sleep quality following hematopoietic stem cell transplantation: longitudinal trajectories and biobehavioral correlates.
Trial report in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Effects of Exercise Programs on Psychoemotional and Quality-of-Life Factors in Adult Patients with Cancer and Hematopoietic Stem Cell Transplantation or Bone Marrow Transplantation: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study.Stem cell research & therapy · 2024Trial
- Acupuncture improves certain aspects of sleep in hematopoietic stem cell transplantation patients: a secondary analysis of a randomized controlled trial.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2023Trial
- Relationship between circadian activity rhythms and fatigue in hospitalized children with CNS cancers receiving high-dose chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- A pilot randomized controlled trial to improve sleep and fatigue in children with central nervous system tumors hospitalized for high-dose chemotherapy.Pediatric blood & cancer · 2019Trial
- Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue.Bone marrow transplantation · 2017Trial
- Symptom clusters and sentinel symptoms during post-transplant recovery in recipients of allogeneic hematopoietic stem cell transplantation: A cross-sectional study.Asia-Pacific journal of oncology nursing · 2025Article
- Article
- Effects of relaxation training combined with music-based intervention on anxiety and depression in patients undergoing hematopoietic stem cell transplantation: a quasi-experimental study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Mindfulness vs. sleep education during autologous hematopoietic cell transplantation for multiple myeloma: Feasibility of a randomized controlled pilot study.Contemporary clinical trials communications · 2025Article
- Evaluation of sleep quality and engraftment in patients undergoing mobilization and hematopoietic stem cell transplantation.Sleep & breathing = Schlaf & Atmung · 2025Observational
- The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy.Stem cell research & therapy · 2025Review
- Biobehavioral mechanisms underlying symptoms in cancer patients with chronic graft-versus-host disease.Brain, behavior, and immunity · 2025Article
- A nursing perspective on inpatient sleep and circadian disruptions for pediatric stem cell transplant patients.Pediatric blood & cancer · 2024Article
- Inflammatory cytokines and depression symptoms following hematopoietic cell transplantation.Brain, behavior, and immunity · 2023Article
- Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation.Frontiers in psychiatry · 2023Article
- Effect of Early Nutritional Support on Quality of Life by EORTC QLQ-C30 in Allogeneic Hematopoietic Stem Cell Transplantation.Blood cell therapy · 2022Article
- Comparison of objective and subjective sleep time and quality in hospitalized recipients of hematopoietic stem cell transplantation.Asia-Pacific journal of oncology nursing · 2022Article
- A biobehavioral intervention to enhance recovery following hematopoietic cell transplantation: Protocol for a feasibility and acceptability randomized control trial.Contemporary clinical trials communications · 2022Article
- Long-term patient-reported neurocognitive outcomes in adult survivors of hematopoietic cell transplant.Blood advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The present study examined changes in sleep quality following hematopoietic stem cell transplantation (HSCT) and investigated associations with biobehavioral factors. Individuals undergoing HSCT for hematologic malignancies (N=228) completed measures of sleep quality and psychological symptoms pre-transplant and 1, 3, 6 and 12 months post transplant. Circulating inflammatory cytokines (IL-6, TNF-α) were also assessed. Sleep quality was poorest at 1 month post transplant, improving and remaining relatively stable after 3 months post transplant. However, approximately half of participants continued to experience significant sleep disturbance at 6 and 12 months post transplant. Mixed-effects linear regression models indicated that depression and anxiety were associated with poorer sleep quality, while psychological well-being was associated with better sleep. Higher circulating levels of IL-6 were also linked with poorer sleep. Subject-level fixed effects models demonstrated that among individual participants, changes in depression, anxiety and psychological well-being were associated with corresponding changes in sleep after covarying for the effects of time since transplant. Sleep disturbance was most severe when depression and anxiety were greatest and psychological well-being was lowest. Findings indicate that sleep disturbance is a persistent problem during the year following HSCT. Patients experiencing depression or anxiety and those with elevated inflammation may be at particular risk for poor sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.