ArticleJAMA neurology2014
Impaired cerebrovascular reactivity in multiple sclerosis.
Article in JAMA neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis-A Systematic Review.Frontiers in neurology · 2022Pooled it
- Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review.BMC neuroscience · 2018Pooled it
- Recent advances in arterial spin labeling MRI for imaging brain tumors.Magma (New York, N.Y.) · 2026Review
- Age differences in spontaneous cerebrovascular reactivity at rest.GeroScience · 2026Article
- Impaired cerebrovascular reactivity is associated with disability and cognitive performance in relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- Vascular Steal in White Matter of Non-Flow-Limited Cerebral Hemispheres Following Acetazolamide Challenge Using Arterial Spin Labeling Magnetic Resonance Imaging.Brain sciences · 2026Article
- Optical coherence tomography angiography biomarkers in multiple sclerosis and neuromyelitis optica spectrum disorders: a systematic review.International journal of retina and vitreous · 2025Review
- Hypoxia in multiple sclerosis.Redox biology · 2025Review
- Cerebrovascular autoregulation in hypoxia: quantitative insights from arterial spin labeling.Frontiers in neuroscience · 2025Review
- Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Variable cerebral blood flow responsiveness to acute hypoxic hypoxia.Frontiers in physiology · 2025Article
- From BBB to PPP: Bioenergetic requirements and challenges for oligodendrocytes in health and disease.Journal of neurochemistry · 2025Review
- Variable Cerebral Blood Flow Responsiveness to Acute Hypoxic Hypoxia.bioRxiv : the preprint server for biology · 2024Article
- Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence.bioRxiv : the preprint server for biology · 2024Article
- COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cellular and molecular mechanisms of the blood-brain barrier dysfunction in neurodegenerative diseases.Fluids and barriers of the CNS · 2024Review
- Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.medRxiv : the preprint server for health sciences · 2024Article
- Differentiation of MS lesions through analysis of microvascular distribution.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- In search of a marker of altered cerebrovascular function in hypertension: Analysis of the fractional amplitude of low-frequency fluctuations in UK Biobank resting state fMRI data.Cerebral circulation - cognition and behavior · 2024Article
- Comparing end-tidal CONeuroImage · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
importanceCerebrovascular reactivity (CVR) is an inherent indicator of the dilatory capacity of cerebral arterioles for a vasomotor stimulus for maintaining a spontaneous and instant increase of cerebral blood flow (CBF) in response to neural activation. The integrity of this mechanism is essential to preserving healthy neurovascular coupling; however, to our knowledge, no studies have investigated whether there are CVR abnormalities in multiple sclerosis (MS).
objectiveTo use hypercapnic perfusion magnetic resonance imaging to assess CVR impairment in patients with MS. DESIGN, SETTING, AND
participantsA total of 19 healthy volunteers and 19 patients with MS underwent perfusion magnetic resonance imaging based on pseudocontinuous arterial spin labeling to measure CBF at normocapnia (ie, breathing room air) and hypercapnia. The hypercapnia condition is achieved by breathing 5% carbon dioxide gas mixture, which is a potent vasodilator causing an increase of CBF. MAIN OUTCOMES AND MEASURES: Cerebrovascular reactivity was calculated as the percent increase of normocapnic to hypercapnic CBF normalized by the change in end-tidal carbon dioxide, which was recorded during both conditions. Group analysis was performed for regional and global CVR comparison between patients and controls. Regression analysis was also performed between CVR values, lesion load, and brain atrophy measures in patients with MS.
resultsA significant decrease of mean (SD) global gray matter CVR was found in patients with MS (3.56 [0.81]) compared with healthy controls (5.08 [1.56]; P = .001). Voxel-by-voxel analysis showed diffuse reduction of CVR in multiple regions of patients with MS. There was a significant negative correlation between gray matter CVR and lesion volume (R = 0.6, P = .004) and a significant positive correlation between global gray matter CVR and gray matter atrophy index (R = 0.5, P = .03). CONCLUSIONS AND RELEVANCE: Our quantitative imaging findings suggest impairment in functional cerebrovascular pathophysiology, by measuring a diffuse decrease in CVR, which may be the underlying cause of neurodegeneration in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.