ArticleJAMA neurology2014
Episodic bradycardia as neurocardiac prodrome to voltage-gated potassium channel complex/leucine-rich, glioma inactivated 1 antibody encephalitis.
Article in JAMA neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Sudden unexpected death in epilepsy and ictal asystole in patients with autoimmune encephalitis: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Clinical Features and Therapeutic Effects of Anti-leucine-rich Glioma Inactivated 1 Encephalitis: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Article
- Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation.Cardiovascular research · 2026Article
- Characterization of cardiac bradyarrhythmia associated with LGI1-IgG autoimmune encephalitis.Frontiers in immunology · 2022Article
- Cardiac Involvement in Movement Disorders.Movement disorders clinical practice · 2021Review
- The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis.Journal of neurology · 2021Review
- Clinical Features and Prognosis in Chinese Patients With Dipeptidyl-Peptidase-Like Protein 6 Antibody-Associated Encephalitis.Frontiers in neurology · 2021Article
- A rare case of anti-LGI1 limbic encephalitis with concomitant positive NMDAR antibodies.BMC neurology · 2020Article
- LGI1-antibody associated epilepsy successfully treated in the outpatient setting.Journal of neuroimmunology · 2020Article
- Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis.Neurology · 2020Article
- Antibody-related movement disorders - a comprehensive review of phenotype-autoantibody correlations and a guide to testing.Neurological research and practice · 2020Review
- Syncope and Twitching at the Emergency Department.The American journal of case reports · 2019Article
- The clinical features, underlying immunology, and treatment of autoantibody-mediated movement disorders.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Clinical characteristics and short-term prognosis of LGI1 antibody encephalitis: a retrospective case study.BMC neurology · 2018Article
- LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes.Journal of neurology, neurosurgery, and psychiatry · 2018Review
- Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology.Brain : a journal of neurology · 2018Review
- Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.Frontiers in neurology · 2018Article
- LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures.Seizure · 2017Article
- Antibody-associated epilepsies: Clinical features, evidence for immunotherapies and future research questions.Seizure · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
importanceVoltage-gated potassium channel complex antibody (VGKCc-Ab) encephalitis is an immunotherapy-responsive syndrome usually associated with causative antibodies that target the leucine-rich, glioma inactivated 1 (LGI1) protein. Although it is expressed throughout the brain, LGI1 is not known to be expressed in cardiac tissue. We describe a novel neurocardiac prodrome of VGKCc-Ab/LGI1-encephalitis. OBSERVATIONS: Among 14 patients with VGKCc/LGI1-Ab encephalitis evaluated in the University of California, San Francisco Autoimmune Encephalitis Clinic and Rapid Dementia Research Program, 3 patients (2 men and 1 woman; aged 53, 55, and 64 years) exhibited episodic bradycardia that preceded the onset of encephalopathy by approximately 2 months and was severe enough to lead to pacemaker implantation. Serum LGI1-Ab results were positive when tested at the time of the subsequent encephalopathy. All 3 patients developed hyponatremia; none had faciobrachial dystonic seizures or malignancy. Brain magnetic resonance imaging was abnormal in 2 cases. None of the patients experienced further symptomatic bradyarrythmias after 1.7 to 7 years of follow-up. CONCLUSIONS AND RELEVANCE: Episodic bradycardia is a distinctive neurocardiac prodrome of VGKCc/LGI1-Ab encephalitis. The neuroanatomical localization most likely relates to insular and temporal lobe involvement, cortical regions that modulate cardiac autonomic function. Further study is needed to determine if recognition of this neurocardiac prodrome and earlier institution of immunosuppression can prevent the development of encephalopathy.
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