ArticlePloS one2014
Breast contrast-enhanced ultrasound: is a scoring system feasible? A preliminary study in China.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Diagnostic Value of Contrast-Enhanced Ultrasonography With SonoVue in the Differentiation of Benign and Malignant Breast Lesions: A Meta-Analysis.Technology in cancer research & treatmentPooled it
- The added value of contrast-enhanced ultrasonography to BI-RADS in the evaluation of breast lesions presenting with pathological nipple discharge.Quantitative imaging in medicine and surgery · 2026Article
- Can the new combined CEUS-BI-RADS score (CB score) reduce the number of breast false positive biopsies? Results from a monocentric study.La Radiologia medica · 2026Article
- Exploring the Application of Contrast-Enhanced Ultrasound in ACR BI-RADS 4A Lesions (≤ 2 cm): A Prospective Multicenter Study in China.The breast journal · 2026Article
- Case Report: A rare case of breast leiomyoma with literature review.Frontiers in oncology · 2026Article
- Article
- The diagnostic value of real-time ultrasound elastography and contrast-enhanced ultrasound in BI-RADS 4A breast lesions.Gland surgery · 2025Article
- Diagnostic test of conventional ultrasonography combined with contrast-enhanced ultrasound in the subcategorization of suspicious Breast Imaging-Reporting and Data System (BI-RADS) 4 breast lesions.Translational cancer research · 2025Article
- Artificial intelligence can extract important features for diagnosing axillary lymph node metastasis in early breast cancer using contrast-enhanced ultrasonography.Scientific reports · 2025Article
- The application of multimodal ultrasound examination in the differential diagnosis of benign and malignant breast lesions of BI-RADS category 4.Frontiers in medicine · 2025Article
- Clinical value of quantitative analysis of Sonazoid-contrast enhanced ultrasound combined with shear wave elastography in discriminating and diagnosing breast tumor characteristics.Frontiers in oncology · 2025Article
- Analysis of Conventional Ultrasound and Contrast-Enhanced Ultrasound Features of Pseudoangiomatous Stromal Hyperplasia.The breast journal · 2025Article
- Current status and future perspectives of contrast-enhanced ultrasound diagnosis of breast lesions.Journal of medical ultrasonics (2001) · 2024Review
- Contrast-enhanced ultrasound to predict malignant upgrading of atypical ductal hyperplasia.Breast cancer research : BCR · 2024Article
- Incremental Value of Shear Wave Elastography and Contrast-Enhanced Ultrasound in the Differential Diagnosis of Breast Non-Mass-Like Lesions.International journal of women's health · 2024Article
- Review
- Value of an expanded range of lesions on contrast-enhanced ultrasound for the diagnosis of hypervascular breast masses.Gland surgery · 2023Article
- Head-to-head comparison of perfluorobutane contrast-enhanced US and multiparametric MRI for breast cancer: a prospective, multicenter study.Breast cancer research : BCR · 2023Article
- The diagnostic value of contrast-enhanced ultrasonography in breast ductal abnormalities.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- The clinical value of conventional ultrasound combined with contrast-enhanced ultrasound in the evaluation of BI-RADS 4 lesions detected by magnetic resonance imaging.The British journal of radiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough many studies about breast contrast-enhanced ultrasound had been conducted, clear diagnostic criteria for evaluating enhancement patterns are still lacking. This study aims to identify significant indicators for breast contrast-enhanced ultrasound and to establish an initial scoring system. MATERIALS AND
methodsTotally 839 patients were included in the study. This study was divided into two parts. 364 patients were included in part 1 while 475 in part 2. Conventional ultrasound and contrast-enhanced ultrasound were used to examine each lesion. Only the cases in part 2 were also examined by elastography. In part 1, Logistic regression analysis was performed to predict significant variables. A 5-point scoring system was developed based on the results. In part 2, the scoring system was used to evaluate all the breast lesions. To evaluate the diagnostic efficacy of the new scoring system, it was compared with the system established for elastography and conventional ultrasound (BI-RADS).
resultsThree independent variables, namely, lesion scope, margin, and shape were selected in the final step of the logistic regression analysis in part 1. In part 2, the area under the ROC (receiver operating characteristic) curve for the contrast-enhanced scoring system was 0.912. The difference in the diagnostic capabilities of the contrast-enhanced scoring system and elastography was not statistically significant (P = 0.17). The difference in the diagnostic capabilities of the contrast-enhanced scoring system and BI-RADS was statistically significant (P<0.001).
conclusionsThe contrast-enhanced patterns of benign and malignant breast tumors are different. The application of a 5-point scoring system for contrast-enhanced ultrasound is clinically promising.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.