ArticlePloS one2014
Systematic genetic analysis identifies Cis-eQTL target genes associated with glioblastoma patient survival.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- mRNA markers for survival prediction in glioblastoma multiforme patients: a systematic review with bioinformatic analyses.BMC cancer · 2024Pooled it
- Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort.PLoS genetics · 2025Article
- Identification of TAPBPL as a novel negative regulator of T-cell function.EMBO molecular medicine · 2021Article
- Identification of Candidate Genes Associated with Susceptibility to Ovarian Clear Cell Adenocarcinoma UsingJournal of clinical medicine · 2020Article
- Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function.British journal of cancer · 2020Article
- Cancer-specific expression quantitative loci are affected by expression dysregulation.Briefings in bioinformatics · 2020Article
- Mapping Tumor-Specific Expression QTLs in Impure Tumor Samples.Journal of the American Statistical Association · 2020Article
- regQTLs: Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors.PLoS genetics · 2018Article
- Prognostic value of NUSAP1 in progression and expansion of glioblastoma multiforme.Journal of neuro-oncology · 2018Article
- Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle.Nature chemical biology · 2018Article
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- Common genetic variation in the germline influences where and how tumors develop.Molecular & cellular oncology · 2017Article
- Proofreading of Peptide-MHC Complexes through Dynamic Multivalent Interactions.Frontiers in immunology · 2017Review
- The role of enhancers in cancer.Nature reviews. Cancer · 2016Review
- The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration.The Journal of biological chemistry · 2015Article
- Article
- Expression and prognostic significance of TCTN1 in human glioblastoma.Journal of translational medicine · 2014Article
Corrections and comments
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior expression quantitative trait locus (eQTL) studies have demonstrated heritable variation determining differences in gene expression. The majority of eQTL studies were based on cell lines and normal tissues. We performed cis-eQTL analysis using glioblastoma multiforme (GBM) data sets obtained from The Cancer Genome Atlas (TCGA) to systematically investigate germline variation's contribution to tumor gene expression levels. We identified 985 significant cis-eQTL associations (FDR<0.05) mapped to 978 SNP loci and 159 unique genes. Approximately 57% of these eQTLs have been previously linked to the gene expression in cell lines and normal tissues; 43% of these share cis associations known to be associated with functional annotations. About 25% of these cis-eQTL associations are also common to those identified in Breast Cancer from a recent study. Further investigation of the relationship between gene expression and patient clinical information identified 13 eQTL genes whose expression level significantly correlates with GBM patient survival (p<0.05). Most of these genes are also differentially expressed in tumor samples and organ-specific controls (p<0.05). Our results demonstrated a significant relationship of germline variation with gene expression levels in GBM. The identification of eQTLs-based expression associated survival might be important to the understanding of genetic contribution to GBM cancer prognosis.
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