ArticleThe Journal of cell biology1989
Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 85 citations in OpenAlex.
- Initiation of focal adhesion assembly by talin and kindlin: A dynamic view.Protein science : a publication of the Protein Society · 2021Review
- Topological data analysis quantifies biological nano-structure from single molecule localization microscopy.Bioinformatics (Oxford, England) · 2020Article
- Structural mechanism of integrin inactivation by filamin.Nature structural & molecular biology · 2015Article
- Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.Nature communications · 2014Article
- Two modes of integrin activation form a binary molecular switch in adhesion maturation.Molecular biology of the cell · 2013Article
- RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration.The Journal of biological chemistry · 2012Article
- Subcellular localization of talin is regulated by inter-domain interactions.The Journal of biological chemistry · 2012Article
- Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Significance of talin in cancer progression and metastasis.International review of cell and molecular biology · 2011Review
- Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation.Protein & cell · 2010Review
- Ovarian hormones regulate expression of the focal adhesion proteins, talin and paxillin, in rat uterine luminal but not glandular epithelial cells.Histochemistry and cell biology · 2009Article
- RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.The Journal of biological chemistry · 2009Article
- Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.The Journal of experimental medicine · 2007Article
- Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.Molecular biology of the cell · 1996Article
- A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant.The Journal of cell biology · 1995Article
- Cytoskeletal domains in the activated platelet.Cell motility and the cytoskeleton · 1995Article
- Focal contact assembly through cytoskeletal polymerization: steady state analysis.Journal of mathematical biology · 1994Article
- Abnormal cytoskeletal assembly in platelets from uremic patients.The American journal of pathology · 1993Article
- Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets.The Journal of cell biology · 1993Article
- A theoretical analysis for the effect of focal contact formation on cell-substrate attachment strength.Biophysical journal · 1993Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Talin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton. We have recently shown that talin is an abundant protein in platelets, cells highly specialized for regulated adhesion. Although talin constitutes greater than 3% of the total protein in intact human platelets, its location within the cells had not been defined. In the work reported here, we have investigated the distribution of talin in resting and activated human platelets by immunofluorescence and immunoelectron microscopy. We have found that talin undergoes an activation-dependent change in its subcellular location. In resting platelets, which are nonadhesive, talin is uniformly distributed throughout the cytoplasm. In contrast, in thrombin- and glass-activated, substratum-adherent platelets, talin is concentrated at the cytoplasmic face of the plasma membrane. This dramatic, regulated redistribution of talin raises the possibility that talin plays a role in the controlled development of platelet adhesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.